There has been dramatic growth in the community of researchers and industrialists working in the area of Green Chemistry. There has been an increasing recognition by a wide-range of scientists and engineers in the chemical enterprise that the framework of Green Chemistry is relevant and enabling to their work.

THE PRINCIPLES OF AND REASONS FOR USING WATER AS A SOLVENT FOR GREEN CHEMISTRY Introduction Binding Two Species Together Driven by the Hydrophobic Effect in Water Aromatic Chlorination Acylation of Cyclodextrins by a Bound Ester Mimics of Metalloenzymes Using the Hydrophobic Effect in Water Mimics of the Enzyme Ribonuclease Mimics of Enzymes that Use Pyridoxamine Phosphate and Pyridoxal Phosphate as Coenzymes Artificial Enzymes Carrying Mimics of Thiamine Pyrophosphate Enolizations and Aldol Condensations Hydrophobic Acceleration of Diels-Alder Reactions Selectivities in Water Induced by the Hydrophobic Effect - Carbonyl Reductions Selectivities in Water Induced by the Hydrophobic Effect - Oxidations Using Hydrophobic Effects in Water to Determine the Geometries of Transition States for Some Important Reactions Conclusion GREEN ACID CATALYSIS IN WATER Introduction Lewis Acids in Water Chiral Lewis Acid-Catalyzed Asymmetric Reactions in Water Bronsted Acid Catalysis in Pure Water Conclusion and Perspective GREEN BASES IN WATER Introduction Types of Bases and Their Use from a Green Point of View Liquid-Liquid Processes Solid-Liquid Processes GREEN OXIDATION IN WATER Introduction Water-Soluble Ligands Oxidations Catalyzed by Metalloporphyrins and Metallophthalocyanines Epoxidation and Dihydroxylation of Olefins in Aqueous Media Alcohol Oxidations in Aqueous Media Aldehyde and Ketone Oxidations in Water Sulfoxidations in Water Conclusion GREEN REDUCTION IN WATER Introduction Water-Soluble Ligands Hydrogenation in Water Transfer Hydrogenation in Water Role of Water Conclusion COUPLING REACTIONS IN WATER Introduction Reaction of Carbonyl Compounds and Derivatives Reaction of Alkenes and Alkynes Reaction of Organic Halides and Derivatives Conclusion "ON WATER" FOR GREEN CHEMISTRY Introduction Pericyclic Reactions Addition of Heteronucleophiles to Unsaturated Carbonyl Compounds Enantioselective Direct Aldol Reactions Coupling Reactions Oxidation Bromination Reactions Miscellaneous Reactions Theoretical Studies Conclusion PERICYCLIC REACTIONS IN WATER. TOWARD GREEN CHEMISTRY Introduction Pericyclic Reaction in Aqueous Media Conclusion NON-CONVENTIONAL ENERGY SOURCES FOR GREEN SYNTHESIS IN WATER (MICROWAVE, ULTRASOUND, AND PHOTO) Introduction MW-Assisted Organic Transformations in Aqueous Media Sonochemical Organic Transformations in Aqueous Media Photochemical Transformations in Aqueous Media Conclusion FUNCTIONALIZATION OF CARBOHYDRATES IN WATER Introduction C-C Bond Formation Reactions C-N Bond Formation Reactions Functionalization of Hydroxy Groups Clyco-Organic Substrates and Reactions in Aqueous Sugar Solutions Conclusion WATER UNDER EXTREME CONDITIONS FOR GREEN CHEMISTRY Introduction Background Recent Progress in HTW Synthesis WATER AS A GREEN SOLVENT FOR PHARMACEUTICAL APPLICATIONS Introduction - Is Water a Green Solvent? Water-Based Enzymatic Processes Processes in Which the Product is Isolated by pH Adjustment to the Isoelectric Point Carbon-Carbon Bond-Forming Cross-Coupling Reactions in Water Pharmaceutical Processes Using Mixed Aqueous Solvents Conclusion WATER AS A GREEN SOLVENT FOR BULK CHEMICALS Introduction Hydroformylation - An Overview Water as Solvent for Hydroformylation Water as Solvent in the Production of 2,7-Octadien-1-ol (Kurayray Process) Conclusion

Green chemistry is a vitally important subject area in a world where being as green and environmentally sound as possible is no longer a luxury but a necessity. Its applications include the design of chemical products and processes that help to reduce or eliminate the use and generation of hazardous substances. The Handbook of Green Chemistry comprises 12 volumes, split into subject-specific sets as follows: Set I: Green Catalysis Set II: Green Solvents • Volume 4: Supercritical Solvents • Volume 5: Reactions in Water • Volume 6: Ionic Liquids Set III: Green Processes Set IV: Green Products Water, an extremely abundant resource, could be used in manufacturing as it is both a “green” solvent (if used properly) and an inexpensive one. One major asset in using water as a solvent is that the hydrophobic effects can lead to suspensions of normally insoluble compounds that facilitate remarkable new chemistry not otherwise achievable. A wide range of classical chemical reactions, normally associated with organic solvents, are discussed within this book.