This book focuses on open issues of new intelligent control paradigms and their usage. Industry 4.0 requires new approaches in the context of secure connection, control, and maintenance of robotic systems, as well as enhancing their interaction with humans. The book presents recent advances in industrial robotics, and robotic design and modeling for various domains, and discusses the methodological foundations of the collaborative robotics concept as a breakthrough in modern industrial technologies. It also describes the implementation of multi-agent models, programs and methods that could be used in future processes for control, condition assessment, diagnostics, prognostication, and proactive maintenance. Further, the book addresses the issue of ensuring the space robotics systems and proposes reliable novel solutions. The authors also illustrate the integration of deep-learning methods and mathematical modeling based on examples of successful robotic systems in various countries, and analyze the connections between robotic modeling and design from the positions of new industrial challenges. The book is intended for practitioners and enterprise representatives, as well as scientists and Ph.D. and Master’s students pursuing research in the area of cyber-physical system development and implementation in various domains.