This book constitutes the refereed proceedings of the 15th International Conference on Unconventional Computation and Natural Computation, UCNC 2016, held in Manchester, UK, in July 2016.The 15 revised full papers presented together with 5 invited papers were carefully reviewed and selected from 30 submissions.

Reachability Problems for Continuous Chemical Reaction Networks.- An All-Optical Soliton FFT Computational Arrangement in the 3NLSE-domain.- Babbage meets Zuse: A Minimal Mechanical Computer.- Generative Power of Matrix Insertion-deletion Systems with Context-free Insertion or Deletion.- Evolving Carbon Nanotube Reservoir Computers.- Global Network Cooperation Catalysed by a Small Prosocial Migrant Clique.- Model-Based Computation.- In vitro Implementation of a Stack Data Structure Based on DNA Strand Displacement.- Analysis of Boolean Logic Gates Logical Complexity for use with Spiking Memristor Gates.- Language Recognition Power and Succintness of Affine Automata.- Training a Carbon-Nanotube / Liquid Crystal Data Classifier Using Evolutionary Algorithms.- Towards Quantitative Verification of Reaction Systems.- Traversal Languages Capturing Isomorphism Classes on Sierpinski Gaskets.- Discrete DNA Reaction-Diffusion Model forImplementing Simple Cellular Automaton.- Universal Totalistic Asynchonous Cellular Automaton and its Possible Implementation by DNA.

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