This book constitutes the refereed proceedings of the 16th International Conference on Software Technologies, ICSOFT 2021, Virtual Event, July 6–8, 2021. The conference was held virtually due to the COVID-19 crisis.The 10 full papers included in this book were carefully reviewed and selected from 117 submissions.

Linked Data as Medium for Stigmergy-based Optimization and Coordination.- Object Parsing Expressions for Unplanned, Unmodified, and Incremental Grammar Reuse.- A Methodology for Organizational Data Science towards Evidence-based Process Improvement.- Feedback Generation for Automatic User Interface Design Evaluation.- Tales from the Code #2: A Detailed Assessment of Code Refactoring's Impact on Energy Consumption.- Towards Power Consumption Optimization for Embedded Systems from a Model-driven Software Development Perspective.- Materializing Microservice-oriented Architecture from Monolithic Object-oriented Source Code.- A Personalized Code Formatter: Detection & Fixing.- Software Framework of Context-aware Reconfigurable Secure Smart Grids.- A Novel Neural Network-based Malware Severity Classification System.