This volume of Advances in Intelligent and Soft Computing contains accepted papers presented at SOCO 2012, held in the beautiful and historic city of Ostrava (Czech Republic), in September 2012. Soft computing represents a collection or set of computational techniques in machine learning, computer science and some engineering disciplines, which investigate, simulate, and analyze very complex issues and phenomena. After a through peer-review process, the SOCO 2012 International Program Committee selected 75 papers which are published in these conference proceedings, and represents an acceptance rate of 38%. In this relevant edition a special emphasis was put on the organization of special sessions. Three special sessions were organized related to relevant topics as: Soft computing models for Control Theory & Applications in Electrical Engineering, Soft computing models for biomedical signals and data processing and Advanced Soft Computing Methods in Computer Vision and Data Processing. The selection of papers was extremely rigorous in order to maintain the high quality of the conference and we would like to thank the members of the Program Committees for their hard work in the reviewing process. This is a crucial process to the creation of a high standard conference and the SOCO conference would not exist without their help.