This book constitutes the refereed proceedings of the First International Conference on Security and Privacy in Digital Economy, SPDE 2020, held in Quzhou, China, in October 2020*.The 49 revised full papers and 2 short papers were carefully reviewed and selected from 132 submissions. The papers are organized in topical sections: ​cyberspace security, privacy protection, anomaly and intrusion detection, trust computation and forensics, attacks and countermeasures, covert communication, security protocol, anonymous communication, security and privacy from social science.*The conference was held virtually due to the COVID-19 pandemic.