This book comprises the proceedings of the International Perm Forum “Science and Global Challenges of the 21st Century” held on October 18th – 23rd, 2021, at Perm State University, Perm, Russia. Global challenges, which determine the main trends in the development of social and economic life in the XXI century, require the integration of specialists in various fields of knowledge. That is why the main principle of this edition is interdisciplinarity, the formation of end-to-end innovation chains, including fundamental and applied research, and the wide application of smart innovations, networks, and information technologies. The authors seek to find synergy between technologies and such fields as computer science, geosciences, biology, linguistics, social studies, historical studies, and economics. The book is of interest to researchers seeking nontrivial solutions at the interface of sciences, digital humanities, computational linguistics, cognitive studies, machine learning, and others.