This book constitutes the proceedings of the 5th International Workshop on Predictive Intelligence in Medicine, PRIME 2022, held in conjunction with MICCAI 2022 as a hybrid event in Singapore, in September 2022.The 19 papers presented in this volume were carefully reviewed and selected for inclusion in this book.

Federated Time-dependent GNN Learning from Brain Connectivity Data with Missing Timepoints.- Bridging the Gap between Deep Learning and Hypothesis-Driven Analysis via Permutation Testing.- Multi-Tracer PET Imaging Using Deep Learning: Applications in Patients with High-Grade Gliomas.- Multiple Instance Neuroimage Transformer.- Intervertebral Disc Labeling With Learning Shape Information, A Look Once Approach.- Mixup augmentation improves age prediction from T1-weighted brain MRI scans.- Diagnosing Knee Injuries from MRI with Transformer Based Deep Learning.- MISS-Net: Multi-view contrastive transformer network for MCI stages prediction using brain 18F-FDG PET imaging.- TransDeepLab: Convolution-Free Transformer-based DeepLab v3+ for Medical Image Segmentation.- Opportunistic hip fracture risk prediction in Men from X-ray: Findings from the Osteoporosis in Men (MrOS) Study.- Weakly-Supervised TILs Segmentation based on Point Annotations using Transfer Learning with Point Detector and Projected-Boundary Regressor.- Discriminative Deep Neural Network for Predicting Knee OsteoArthritis in Early Stage.- Long-Term Cognitive Outcome Prediction in Stroke Patients Using Multi-Task Learning on Imaging and Tabular Data.- Quantifying the Predictive Uncertainty of Regression GNN Models Under Target Domain Shifts.- Investigating the Predictive Reproducibility of Federated Graph Neural Networks using Medical Datasets.- Learning subject-specific functional parcellations from cortical surface measures.- A Triplet Contrast Learning of Global and Local Representations for Unannotated Medical Images.- Predicting Brain Multigraph Population From a Single Graph Template for Boosting One-Shot Classification.- Meta-RegGNN: Predicting Verbal and Full-Scale Intelligence Scores using Graph Neural Networks and Meta-Learning