This book constitutes the proceedings of the 6th International Conference on Lean and Agile Software Development, LASD 2022, which was held online on January 22, 2022.   The conference received a total of 29 submissions, of which 9 full papers, 1 short paper and 1 position paper are included in this volume. In addition, the volume contains one keynote paper in full paper length.   Topics discussed in this volume cover various aspects of agile software development and range from agile testing, to agile effort estimation, an agile approach to model-driven development, and remotely working agile teams.