This book contains the refereed proceedings of the 15th International Conference on Knowledge Management in Organizations, KMO 2021, held in Kaohsiung, Taiwan, in July 2021. The 28 full papers and 9 short papers accepted for KMO 2021 were selected from 86 submissions and are organized in topical sections on: knowledge management models and analysis;  knowledge transfer and learning; knowledge and service innovation; knowledge and organization; information systems and information science; privacy and security; intelligent science and data mining; AI and new trends in IT.