This book constitutes the refereed post-conference proceedings of the Second IFIP International Cross-Domain Conference on Internet of Things, IFIPIoT 2019, held in Tampa, USA, in October/ November 2019.The 11 full papers presented were carefully reviewed and selected from 22 submissions.

IoT Applications.- Architecting Systems-of-Systems of Self-Driving Cars for Platooning on the Internet-of-Vehicles with SosADL.- Energy Efficiency in Smart Buildings: An IoT-based Air Conditioning Control System.- Toward Blockchain Technology in IoT Applications: An Analysis for E-health Applications.- Context Rasoning and Situational Awareness.- I2VSM Approach: Self-Monitoring of Patients Exploring Situational IoT Awareness.- An IoT Proposal for the Irrigation Management exploring Context Awareness.- An IoT Architecture to Provide Hybrid Context Reasoning.- IoT Security.- REDEM: Real-time Detection and Mitigation of Communication Attacks in Connected Autonomous Vehicle Applications (Invited).- Trust in IoT Devices: A Logic Encryption Perspective.- Latent Space Modeling for Cloning Encrypted PUF-based Authentication.- Lightweight Countermeasure to Differential-Plaintext Attacks on Permutation Ciphers.- Smart and Low Power IoT.- Challenges in the Design of Integrated Systems for IoT (Invited).- Mixed Precision Quantization Scheme for Re-configurable ReRAM Crossbars Targeting Different Energy Harvesting Scenarios (Invited).- Smart Network Architectures.- Toward Holistic Integration of Computing and Wireless Networking (Invited).- The thing about the Internet of Things: Scoping the Social Science discourse in IoT research.- Evaluating Edge Processing Requirements in Next Generation IoT Network Architectures.- Smart System Design and IoT Education.- Good-Eye: A Combined Computer-Vision and Physiological-Sensor based Edge Device for Full-Proof Detection of Fall of Adults (Invited).- Building a Low-cost and State-of-the-art IoT Security Hands-on Laboratory (Invited).- Curriculum Design Requirements and Challenges for the first Bachelor's Degree on IoT in the US (Invited).- IoT in Smart Grid: Energy Management Opportunities and Security Challenges (Invited).