This book is composed of a selection of articles from the 11st World Conference on Information Systems and Technologies, held between 4 and 5 of April 2023, at Sant'Anna School of Advanced Studies, in Pisa, Italy. WorldCIST is a global forum for researchers and practitioners to present and discuss recent results and innovations, current trends, professional experiences, and challenges of modern Information Systems and Technologies research, together with their technological development and applications. The main and distinctive topics covered are: A) Information and Knowledge Management; B) Organizational Models and Information Systems; C) Software and Systems Modeling; D) Software Systems, Architectures, Applications, and Tools; E) Multimedia Systems and Applications; F) Computer Networks, Mobility, and Pervasive Systems; G) Intelligent and Decision Support Systems; H) Big Data Analytics and Applications; I) Human–Computer Interaction; J) Ethics, Computers, and Security; K) Health Informatics; L) Information Technologies in Education; M) Information Technologies in Radiocommunications; and N) Technologies for Biomedical Applications.