This book constitutes the proceedings of the 33rd International Conference on Parallel and Distributed Computing, Euro-Par 2022, held in GLasgow, UK, in August 2022.The 25 full papers presented in this volume were carefully reviewed and selected from 102 submissions. The conference Euro-Par 2022 covers all aspects of parallel and distributed computing, ranging from theory to practice, scaling from the smallest to the largest parallel and distributed systems, from fundamental computational problems and models to full-fledged applications, from architecture and interface design and implementation to tools, infrastructures and applications.