This book constitutes the refereed proceedings of the 19th International Conference on Engineering Applications of Neural Networks, EANN 2019, held in  Xersonisos, Crete, Greece, in May 2019.The 35 revised full papers and 5 revised short papers presented were carefully reviewed and selected from 72 submissions. The papers are organized in topical sections on AI in energy management - industrial applications; biomedical - bioinformatics modeling; classification - learning; deep learning; deep learning - convolutional ANN; fuzzy - vulnerability - navigation modeling; machine learning modeling - optimization; ML - DL financial modeling; security - anomaly detection; 1st PEINT workshop.