This book constitutes the refereed proceedings of the 15th International Baltic Conference on Digital Business and Intelligent Systems, Baltic DB&IS 2022, held in Riga, Latvia, in July 2022. The 16 revised full papers and 1 short paper presented were carefully reviewed and selected from 42 submissions. The papers are centered around topics like architectures and quality of information systems, artificial intelligence in information systems, data and knowledge engineering, enterprise and information systems engineering, security of information systems.