This book constitutes the post-conference proceedings of the 22nd International Conference on Data Analytics and Management in Data Intensive Domains, DAMDID/RCDL 2020, held in Voronezh, Russia, in October 2020*.The 16 revised full papers and two keynotes were carefully reviewed and selected from 60 submissions. The papers are organized in the following topical sections: data Integration, conceptual models and ontologies; data management in semantic web; data analysis in medicine; data analysis in astronomy; information extraction from text.* The conference was held virtually due to the COVID-19 pandemic.