The 3-volume set CCIS 1252 until CCIS 1254 constitutes the refereed proceedings of the 6th International Conference on Artificial Intelligence and Security, ICAIS 2020, which was held in Hohhot, China, in July 2020. The conference was formerly called “International Conference on Cloud Computing and Security” with the acronym ICCCS. The total of 178 full papers and 8 short papers presented in this 3-volume proceedings was carefully reviewed and selected from 1064 submissions. The papers were organized in topical sections as follows: Part I: artificial intelligence; Part II: artificial intelligence; Internet of things; information security; Part III: information security; big data and cloud computing; information processing.