Transposition Diameter and Lonely Permutations.-Extending the Algebraic Formalism for Genome Rearrangements.-On the Approximation Ratio of Algorithms for Sorting by Transpositions without Using Cycle Graphs.-A Comparison of Three Heuristic Methods for Solving the Parsing.-Problem for Tandem Repeats.-RNA Folding Algorithms with G-Quadruplexes.-Molecular Dynamics for Simulating the Protein Folding Process Usingthe 3D AB Off-Lattice Model.-A Bioconductor Based Workflow for Z-DNA Region Detection.-Prediction of Transcription Factor Binding Sites by Integrating DNase Digestion and Histone Modification.-Evaluating Correlation Coefficients for Clustering Gene Expression.-Profiles of Cancer.-Associating Genotype Sequence Properties to Haplotype Inference Errors on Molecular Descriptors.-Phylogenetic Distance Computation Using CUDA.-Exploring Molecular Evolution Reconstruction Using a Parallel Cloud.-How Bioinformatics Enables Livestock Applied Sciences in the Genomic.-

This book constitutes the thoroughly refereed proceedings of the 16th East-European Conference on Advances in Databases and Information Systems (ADBIS 2012), held in Poznan, Poland, in September 2012. The 32 revised full papers presented were carefully selected and reviewed from 122 submissions. The papers cover a wide spectrum of issues concerning the area of database and information systems, including database theory, database architectures, query languages, query processing and optimization, design methods, data integration, view selection, nearest-neighbor searching, analytical query processing, indexing and caching, concurrency control, distributed systems, data mining, data streams, ontology engineering, social networks, multi-agent systems, business process modeling, knowledge management, and application-oriented topics like RFID, XML, and data on the Web.