Buso Renkinis the story of teenager Kazuki Muto who dies trying to save a girl who was being attacked by an eerie monster. The following morning, Kazuki wakes wondering whether it was all a dream. But the girl, the monster, and his death are all real! The girl, Tokiko Tsumura, was actually trying to slay the homunculus (a beast that can take the form of humans, but whose main source of food is people), but Kazuki got in her way. To revive Kazuki, Tokiko replaces his heart with a "kakugane," an alchemic device that allows him to summon a lance with which to fight the monsters. It turns out that Tokiko is a member of Renkin Kenshi(Alchemist Soldiers), an organization sworn to protect the world from the diabolical creatures. Soon, Kazuki joins Tokiko in her quest to terminate the sinister being that creates and controls the homunculus. Talk about being at the wrong place at the wrong time! High school student Kazuki Muto had no clue what he was in for when he rescued damsel in distress Tokiko from a monster known as a 'homunculus'. Disguised as humans who actually eat humans, homunculi are malevolent creatures that affix themselves to people's brains, and once fully grown, the only thing that can annihilate them is a weapon called Buso Renkin! Follow the adventures of Kazuki after he discovers that it was actually Tokiko who saved hislife by implanting a kakugane, an alchemical device that transforms into a buso renkin, to replace his heart!