Process development bridges the gap between the laboratory synthesis of an organic compound and its industrial manufacture on a large scale. In this concise text the authors use real examples to show the problems which may be encountered in scaling up chemical syntheses and the ways in which these problems may be overcome. The major part of the book is devoted to genuine case histories from ICI/Zeneca Pharmaceuticals. Through a range of carefully chosen examples, the book explains how it is possible to synthesise multi-kilogram quantities of a new organic compound which have been made in the laboratory only on the milligram scale. A wide range of aliphatic, aromatic, and heterocyclic compounds is covered. The book will be of particular value to research chemists who are involved in the development phase of novel compounds and to advanced undergraduate and postgraduate students interested in the fine chemicals industry.
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Process development bridges the gap between the laboratory synthesis of an organic compound and its industrial manufacture on a large scale. This book uses real examples to show the range of problems which may be encountered in scaling up chemical syntheses and the ways in which they may be overcome.
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Introduction ; 1. Scale up issues ; 2. Environmental and regulatory issyes ; 3. Fun with cephalosporins ; 4. Thromboxane antagonists ; 5. Homochiral thrombozane antagonists ; 6. H2 blockers ; 7. Development of a manufacturing route for cloprostenol sodium ; 8. Synthesis of a potentially anti-obesity agent ; 9. Reagents for large scale operation
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excellent..volume
`excellent..volume' Chemistry in Britain
The only introductory textbook on process development Includes real case histories from ICI/Zeneca Pharmaceuticals Provides students with an insight into research in the fine chemicals industry
The only introductory textbook on process development Includes real case histories from ICI/Zeneca Pharmaceuticals Provides students with an insight into research in the fine chemicals industry

Produktdetaljer

ISBN
9780198558248
Publisert
1995
Utgiver
Vendor
Oxford University Press
Vekt
206 gr
Høyde
245 mm
Bredde
188 mm
Dybde
6 mm
Aldersnivå
U, 05
Språk
Product language
Engelsk
Format
Product format
Heftet
Antall sider
98