The book spans a scientific research program elegantly developed by Roberto Camagni, an eminent regional scientist, who has offered ground-breaking ideas in regional and urban economics throughout his academic career. In addition to bringing together a selection of Professor Camagni’s most influential works, the book presents syntheses and interpretations of his ideas by respected colleagues and by his students. In regional economics, space as territory, which plays an active role in innovation processes and in regional growth patterns; territorial capital as a synthetic concept of differentiated regional growth assets; and sources of regional competitiveness are only a few of the main ideas that emerged in regional economics thanks to this inspiring mind. In urban economics, he paved the way towards a new theoretical interpretation of the existence of the city and of its dynamics. His theory of city networks overcame the limits of Christaller’s and Lösch’s spatial approach to the city, with a solid economic conceptualization of spatial city network structures. All theories are accompanied by sound policy analysis, helping to contribute to the design and implementation of appropriate spatial policies at the European level.