"The editors and authors have done an excellent job ... Moss and Henley make a valuable contribution by highlighting major advances in the membrane trafficking of specific neurotransmitter receptors and ion channels ... this book is a most interesting and thought-provoking read." Nature Cell Biology

A volume in the Molecular and Cellular Neurobiology series. This book reviews the recent advances in our understanding of the molecular and cellular mechanisms that control the assembly, transport, targeting and anchoring of the protein complexes making up the most important ion channels and receptor families, fundamental to synaptic function. Improved understanding of these processes is expected to reveal novel therapeutic targets relevant to a range of disease states. The first section of the book contains three chapters dealing with cation channels and provides an accessible, succinct and comprehensive account of what is known about the structures and the assembly and targeting of these multimeric proteins. The focus of the book then moves on to cover ligand-gated ion channels with two chapters on acetylcholine receptors. The final section of the book contains four chapters covering the excitatory and inhibitory amino acid receptors. Receptor and Ion-Channel Trafficking provides an integrated overview of the significant recent advances in the field of molecular neurobiology and will be essential reading for all researchers in neuroscience, neurobiology, biochemistry, cellular and molecular biology.
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This book reviews the recent advances in our understanding of the the molecular and cellular mechanisms regulating the targeted movement (trafficking) of receptors and ion channels in neurones - mechanisms fundamental to synaptic function.
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ION CHANNELS ; 1. Voltage-gated sodium channels ; 2. The assembly and targeting of potassium channels ; 3. Assembly and targeting of voltage-dependent calcium channels ; ACETYLCHOLINE RECEPTORS ; 4. Targeting of acetylcholine receptors to the postsynaptic endplate of the nerve-muscle synapse ; 5. Assembly and targeting of neuronal nicotinic acetylcholine receptors ; AMINO ACID RECEPTORS ; 6. AMPA/kainate receptors ; 7. NMDA receptor targeting ; 8. Structure, assembly and targeting of glycine receptors ; 9. GABAA and GABAC receptors: regulation of assembly, localization, clustering and turnover
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Produktdetaljer

ISBN
9780192632241
Publisert
2002
Utgiver
Vendor
Oxford University Press
Vekt
646 gr
Høyde
248 mm
Bredde
174 mm
Dybde
18 mm
Aldersnivå
P, 06
Språk
Product language
Engelsk
Format
Product format
Innbundet
Antall sider
236