From large cross-sectional studies of autopsy material, it seems as if a time course of Alzheimer's Disease, at least on average, can be mapped out: a pattern of hierarchical vulnerability for neuronal loss and neurofibrillary tangles beginning in medial temporal lobe structures proceeding through association areas.

Neuropathology of Alzheimer’s disease, as Seen in Fixed Tissues.- Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer’s Disease.- The Living Brain and Alzheimer’s Disease.- In Vivo Imaging of Alzheimer Pathology in Transgenic Mice Using Multiphoton Microscopy.- In Vivo Magnetic Resonance of Amyloid Plaques in Alzheimer’s Disease Model Mice.- Measuring Progression in Alzheimer’s Disease Using Sserial MRI: 4D MRI.- Validating MRI Measures of Disease Stage and Progression in Alzheimer’s Disease.- Dynamic Mapping of Alzheimer’s Disease.- Development of Benzothiazole Amyloid-Imaging Agents.- First PET Study with a Benzothiazol Amyloidimaging Agent (PIB) in Alzheimer’s Disease Patients and Hhealthy Volunteers.- Mild Cognitive Impairment (MCI): Predicting Conversion to Clinically Probable Alzheimer’s Disease with Fluoro-Deoxy-Glucose PET.- Positron Emission Tomography and Magnetic Resonance Imaging in the Study of Cognitively Normal Persons at Differential Genetic Risk for Alzheimer’s Dementia.

How can we link the critical observations performed at autopsy with the events that occur over the previous twenty years of Alzheimer’s Disease? This is the problem posed to a group of our colleagues who are using state-of-the-art neural imaging methods in patients and in animal models to illuminate the natural history of the disease – in the living brain.

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