This book constitutes the refereed proceedings of the First International Conference on Formal Methods in Macro-Biology, FMMB 2014, held in Nouméa, New Caledonia, in September 2014.The 7 revised full and 3 short papers presented together with 7 invited presentations were carefully reviewed and selected from 17 submissions.

Model-Checking in Systems Biology - From Micro to Macro.- Developing Quantitative Methods in Community Ecology: Predicting Species Abundances from Qualitative Web Interaction Data.- Understanding How Biodiversity Is Distributed in Space and Time.- Computing Longevity: Insights from Controls.- Control of a Bioreactor with Quantized Measurements.- External Interactions on Hybrid Models of Biological Systems.- Attractor Equivalence: An Observational Semantics for Reaction Networks.- Petri Nets Are a Biologist’s Best Friend.- 50 Shades of Rule Composition: From Chemical Reactions to Higher Levels of Abstraction.- A Logical Framework for Systems Biology.- Disentangling the Effects of Habitat and Protection on Coral Reef Fish Communities in Long-Established Marine Reserves.- The Challenges of Developing Spatially Explicit Network Models for the Management of Disease Vectors in EcologicalSystems.- Evaluating Management Scenarios for Fished Resources of the New Caledonian Lagoon Using a Spatially-Explicit Model.- Completing SBGN-AF Networks by Logic-Based Hypothesis Finding.