Cancer Stem Cells and Signaling Pathways explores the mechanism of cancer stem cell signaling pathways in cancer advancement, serving as an ideal reference guide for investigators with valuable answers to problems associated with anti-cancer treatments and an understanding of the crosstalk among the signaling pathways in CSC regulation. Despite recent advances in tumor therapy and a greater understanding of their biology, tumors continue to be a prevalent and fatal worldwide. According to a novel paradigm in tumor biology, a small percentage of the cells within a tumor known as cancer stem cells (CSCs) are predicted as a crucial population for tumor progression.
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1. Origin of cancer stem cells (CSCs) and the signalling pathways associated with stem cells and cancer stem cells 2. The importance of niche in therapeutic strategies targeting normal and cancer stem cells 3. Cancer stem cell research: A phosphoproteomic approach 4. Role of Mechanotransduction in stem cells and cancer progression 5. Cancer stem cell signaling in neuroblastoma progression- In touch with reality 6. Role of cancer stem cells in developing chemoresistance of solid tumor 7. The cell surface markers and signaling pathways of cancer stem cells: Target for potent Therapeutics 8. Lung cancer stem cells markers and its potential therapeutic molecular targets 9. Role of cancer stem cells in maintenance of tumor heterogeneity in brain tumors 10. Colorectal cancer stem cells: Overview and potential targeted therapy 11. Pancreatic cancer stem cells and inflammation: Milestones achieved and challenges ahead 12. Epigenetic modification: Key regulator of reprogramming in cancer stem cells 13. Regulation of cancer stemness, cell signaling, reactive oxygen species, and microRNAs in cancer stem cells 14. The stem cell niche: Key role on cell therapy in regenerative medicine 15. Controlled and targeted proliferation of stem cells for therapeutic application 16. MicroRNAs as theranostics: Combating breast cancer stem cells 17. Chemical approaches to stem cell and signaling pathways for therapeutics 18. Responsive biomimetic nanocarriers and its role in stem cell-based targeting therapeutics 19. Stem cell signalling in nephroblastoma with reference to Wilms tumor 20. Brain cancer stem cells: Overview and potential targeted therapy 21. Pancreatic cancer and stem cell 22. Epigenetic modulation of cancer stem cells in vitro 3D models 23. Epigenetic signalling: Regulation of cancer stem cells in colorectal cancer 24. Cancer stem cells, signalling pathways and chemopreventive effects of phytochemicals in androgen-regulated cancers 25. Biomarkers and signalling pathways of esophageal cancer stem cells: promising targets to limit the metastatic potential and stemness. 26. miRNA signalling networks of therapeutic interest involved in angiogenesis regulation by cancer stem cells 27. An altered metabolic landscape drives quiescence to the reawakening of cancer stem cells. 28. Canonical WNT signaling pathway in cancer stem cells and potential inhibitors of therapeutic importance 29. A mechanistic view of the role of thyroid cancer stem cells in microenvironment 30. Cancer stem cells and maintenance of tumor heterogeneity/microenvironment 31. An overview of the role of proto-oncogenes in tissue-specific stem cells 32. Components of cancer stem cells microenvironment: Influence on the tumorigenic property and stemness in cancer stem cells. 33. An overview of hepatocellular carcinoma stem cells and potential targeted therapies 34. Cancer stems cell-derived exosomes: What is known to date 35. Signaling mechanisms of chemoresistance in breast cancer stem cells for therapeutics
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A presentation of recent research on different aspects of stem cells, cancer stem cells, and signaling pathways in cancer therapies
Presents cancer stem characteristics and their signaling pathways Highlights the use of animal models for cancer research, the use of genetically modified stem cells to deliver antitumor agents, and the significance of stem cell signaling in drug discovery Covers basic and translational research appropriate for scientists and clinicians exploring alternative treatments for various cancers
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Produktdetaljer

ISBN
9780443132124
Publisert
2023-11-01
Utgiver
Elsevier Science Publishing Co Inc; Academic Press Inc
Vekt
1430 gr
Høyde
235 mm
Bredde
191 mm
Aldersnivå
P, 06
Språk
Product language
Engelsk
Format
Product format
Heftet
Antall sider
698

Om bidragsyterne

Prof. Surajit Pathak, PhD, is a professor at Chettinad Academy of Research and Education (CARE), Chennai, India since 2015. He was previously a principal research scientist (2022 June–Dec 2022) at Linkoping University, Linkoping, Sweden. He received his PhD degree from India in 2007 and completed his postdoctoral training (2007–15) from the University of Alabama, United States, the University of Padova, Italy, and the University of Linkoping, Sweden. His current research focuses on “Biomarker discoveries for early detection of colorectal cancer.” He has published more than 100 research articles in peer-reviewed international journals of repute with 2233 citations and 27 H-index. Dr. Pathak has edited Elsevier book “Stem Cells and Aging” in 2021. He is the member of various professional research bodies of India, including the Indian Association of Cancer Research and the Indian Science Congress. Dr. Antara Banerjee, PhD, is presently working as an associate professor at CARE, Chennai from 2016 to date. After completing her PhD in 2008 from India, Dr. Banerjee pursued her postdoctoral work at the University of Padova, Italy and Linkoping University, Sweden (2009–15). She has published over 95 peer-reviewed research articles in international and national journals with citation index-1408 and H-index 19. The Banerjee’s lab at Chettinad Hospital and Research Institute is now focused on understanding the role of mesenchymal stem cells niche in tissue regeneration and exploring signaling pathways in governing stem cell fate. She is the editor of Elsevier book “Stem Cells and Aging” in 2021. She is the member of various professional research bodies, including the Indian Association of Cancer Research and the Indian Science Congress.