This book constitutes the proceedings of the 18th International Symposium on Bioinformatics Research and Applications, ISBRA 2022, held in Haifa, Israel, in November 14–17, 2022.The 30 full papers and 4 short papers presented in this book were carefully reviewed and selected from 72 submissions. Biomedical data;

MLMVFE: A Machine Learning Approach Based on Muli-View Features Extraction for Drug-Disease Associations Prediction.- STgcor: A Distribution-based Correlation MeasurementMethod for Spatial Transcriptome Data.- Automatic ICD Coding based on Multi-granularity Feature Fusion.- Effectively Training MRI Reconstruction Network via Sequentially Using  Undersampled k-Space Data with Very Low Frequency Gaps.- Fusing Label Relations for Chinese EMR Named Entity Recognition with Machine Reading Comprehension.- Private Epigenetic PaceMaker Detector using Homomorphic Encryption - Extended Abstract.- NIDN: Medical Code Assignment via Note-Code Interaction Denoising Network.- Research on the prediction method of disease classification based on imaging features.- M-US-EMRs: A Multi-Modal Data Fusion Method of Ultrasonic Images and Electronic Medical Records Used for Screening of Coronary Heart Disease.- Transposition Distance Considering Intergenic Regions for Unbalanced Genomes.- An SMT-based Framework for Reasoning about Discrete Biological Models.- ARGLRR: An Adjusted Random Walk Graph Regularization Sparse Low-rank Representation Method for Single-cell RNA-sequencing Data Clustering.- An Efficient and User-friendly Software for PCR Primer Design for Detection of Highly Variable Bacteria.- A Network-Based Voting Method for Identification and Prioritization of Personalized Cancer Driver Genes.- TDCOSR: A multimodality fusion framework for association analysis between genes and ROIs of Alzheimer’s disease.- Policy-based Hypertension Monitoring using Formal Runtime Verification Monitors.- Deep learning-enhanced MHC-II presentation prediction and peptidome deconvolution.- MMLN: Leveraging Domain Knowledge for Multimodal Diagnosis.- Optimal sequence alignment to ED-strings.- Heterogeneous PPInetwork representation learning for protein complex identification.- A Clonal Evolution Simulator for Planning Somatic Evolution Studies.- Prediction of Drug-disease Relationship on Heterogeneous Networks Based on Graph  Convolution.- t-SNE Highlights Phylogenetic and Temporal Patterns of SARS-CoV-2 Spike and Nucleocapsid Protein Evolution.- MPCDDI: A Secure Multiparty Computation-based Deep Learning Framework for Drug-drug Interaction Predictions.- A Multimodal Data Fusion-based Deep Learning Approach for Drug-Drug Interaction Prediction.- GNN-Dom: an unsupervised method for protein domain partition via protein contact map.- A Locality-Constrained Linear Coding-Based Ensemble Learning Framework for Predicting Potentially Disease-Associated MiRNAs.- Gaussian-enhanced Representation Model for Extracting Protein-Protein Interactions Affected by Mutations.- Distance Profiles of Optimal RNA Foldings.- 2D Photogrammetry Image of Adolescent Idiopathic Scoliosis Screening Using Deep Learning.- EMRShareChain: A Privacy-Preserving EMR Sharing System Model Based on the Consortium Blockchain.- Simulating Spiking Neural Networks based on SW26010pro.- Entropy Based Clustering of Viral Sequences.- A Tensor Robust Model Based on Enhanced Tensor Nuclear Norm and Low-Rank Constraint for Multi-view Cancer Genomics Data.