SMART Vaccines—Strategic Multi-Attribute Ranking Tool for Vaccines—is a prioritization software tool developed by the Institute of Medicine that utilizes decision science and modeling to help inform choices among candidates for new vaccine development. A blueprint for this computer-based guide was presented in the 2012 report Ranking Vaccines: A Prioritization Framework: Phase I. Ranking Vaccines: A Prioritization Software Tool,Phase II extends the proof-of-concept presented in the Phase I report, which was based on multi-attribute utility theory. This report refines a beta version of the model developed in the Phase I report and presents its next iteration, SMART Vaccines 1.0. Ranking Vaccines: Phase II discusses the methods underlying the development, validation, and evaluation of SMART Vaccines 1.0. It also discusses how SMART Vaccines should—and, just as importantly, should not—be used. The report also offers ideas for future enhancements for SMART Vaccines as well as for ideas for expanded uses and considerations and possibilities for the future. Table of ContentsFront MatterSummary1 Introduction: New Vaccines and SMART Vaccines2 Refinements to the SMART Vaccines Model3 Data Synthesis, Software Redesign, and Evaluation4 Observations and Looking ForwardReferencesAppendix A: Computational Modeling for SMART VaccinesAppendix B: Candidate Disease ProfilesAppendix C: Data Sources and Methodology for SMART VaccinesAppendix D: Verification and Analyses of the SMART Vaccines Computational ModelAppendix E: Stakeholder SpeakersAppendix F: Biographical Information