Stimuli-Responsive Hydrogels for Ophthalmic Drug Delivery covers fundamental aspects in the preparation of polymeric in-situ, stimuli-responsive hydrogels, including properties, characterization, chemistry, and fabrication of these hydrogels. The book will help the reader select the most appropriate material and design for the desired application. The book goes on to review applications in ophthalmic drug delivery, covering in vitro and in vivo models, animal models, preclinical testing, patents, and more. This is a must-have reference for researchers and academics in the fields of materials science, biomaterials, pharmacology and polymer science, with an interest in clinical aspects of hydrogel design and application.
Les mer
Part I: Properties and Preparation
1. Introduction to polymeric in-situ forming hydrogels
2. Biopolymers for in-situ forming hydrogels: synthesis, characterization, and toxicity
3. Chemistry and applications of biopolymer stimuli-responsive in-situ gels
4. Design, engineering, and fabrication of biopolymer in-situ forming hydrogels
5. Process optimization for design and fabrication of biopolymer stimuli-responsive
hydrogels
6. Properties of biopolymeric in-situ hydrogels
7. Swelling and drug release kinetics of biopolymer in-situ forming hydrogels
8. Structural and load-bearing characteristics of biopolymer in-situ forming hydrogels
9. Functionalization of in-situ forming biopolymer hydrogels
Part II: Applications in Ophthalmic Drug Delivery
10. Eye anatomy, physiology, and ocular barriers
11. In vitro and in vivo models in ophthalmic drug delivery
12. Formulation and ocular drug delivery routes
13. Clinical indications of stimuli-responsive hydrogels in ophthalmic drug delivery
14. Natural and synthetic materials for stimuli-responsive hydrogels in ophthalmic drug delivery
15. Characteristics and kinetics of in-situ forming hydrogels in ophthalmic drug delivery
16. Cell-laden stimuli-responsive hydrogels in ophthalmic drug delivery
17. Animal models and preclinical tests for evaluation of stimuli-responsive hydrogels in ophthalmic drug delivery
18. Biopolymer-based in-situ forming hydrogels: from laboratory to practical application
19. Commercially available stimuli-responsive hydrogels for ophthalmic drug delivery
20. Advantages and challenges of biopolymer in-situ hydrogels for ophthalmic drug delivery
21. Patents for biopolymer in-situ hydrogels for ophthalmic drug delivery
Les mer
Provides a comprehensive review of in-situ and stimuli-responsive biopolymer hydrogels for ocular drug delivery
Provides step-by-step coverage for engineering in-situ and stimuli-responsive hydrogels, from design, characterization, and toxicity considerations to fabrication, process optimization, and drug release kinetics
Utilizes an interdisciplinary approach, bringing together authors from pharmacology, polymer science, and medical backgrounds
Details the advantages and challenges of using stimuli-responsive hydrogels for ophthalmic drug delivery, with a focus on clinical translation
Les mer
Produktdetaljer
ISBN
9780323991568
Publisert
2024-05-10
Utgiver
Elsevier Science Publishing Co Inc; Woodhead Publishing
Vekt
1000 gr
Høyde
229 mm
Bredde
152 mm
Aldersnivå
P, UP, 06, 05
Språk
Product language
Engelsk
Format
Product format
Heftet
Antall sider
672