In this issue of Cardiology Clinics, guest editor Dr. Antonio H. Frangieh brings his considerable expertise to the topic of Update in Structural Heart Interventions. Top experts discuss key topics such as treatment of incident coronary artery disease in patients with severe aortic valve stenosis; electrosurgery in structural heart interventions; 3-dimensional multiplane reconstruction imaging for guiding tricuspid valve interventions; coronary risk in TAVR; treatment of bicuspid aortic valve stenosis in the transcatheter treatment era; and more. Contains 11 relevant, practice-oriented topics including lifetime management in treating aortic valve stenosis; left atrial appendage closure: therapy overview and future perspective; structural challenges in native atrioventricular valves replacement; TAVR for aortic insufficiency; patent foramen ovale and atrial septal defect; and more. Provides in-depth clinical reviews on structural heart interventions, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.