Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

1 Animal Models for Tumor Suppressor Genes.- 2 Viral Oncoproteins as Probes for Tumor Suppressor Function.- 3 Tumor Suppressors in Metastasis.- 4 Apoptosis: Machinery of Cell Death in Development and Cancer.- 5 Drug Discovery in Oncology.- 6 Retinoblastoma Protein in Growth Control and Differentiation.- 7 p53 Tumor Suppressor Protein.- 8 p16 Tumor Suppressor.- 9 DNA Mismatch Repair in Tumor Suppression.- 10 PTEN: Regulator of Phosphoinositide 3-Kinase Signal Transduction.- 11 Neurofibromatoses.- 12 Von Hippel-Lindau Disease: Clinical and Molecular Aspects.- 13 Wilms’ Tumor: A Developmental Anomaly.- 14 Fanconi Anemia Pathway and Cancer Susceptibility.

While the war against cancer has seen great advances in our understanding of cell proliferation and its regulation at the molecular level, the translation of this knowledge into effective therapies has lagged well behind. In Tumor Suppressor Genes in Human Cancer, David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Additional coverage is accorded animal models, viral oncoproteins as probes, and cancer metastasis. An extensive chapter on cancer drug discovery is provided to help integrate the new molecular oncology with technologies which fuel the pragmatic search for improved cancer therapeutics. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

"...brings together a panel of experts in the field of cancer biology, with almost half of the authors from Harvard Medical School. ...describes he role of tumor suppressor genes in human cancer. It details a current view of these important genes and highlights clinically relevant aspects of the strides made in the field of tumor suppressor biology. ...The book is well organized with most chapters having figures and tables to clarify the points made in the text. It is well referenced....This book provides readable, yet thorough, coverage of the field of tumor suppressor biology." -Doody's Health Sciences Book Review Journal