Chapter 1 - Heart physiology and heart diseases, Djordje Jakovljevic, Nenad Filipovic.- Chapter 2 - Finite element modeling, Nenad Filipovic.- Chapter 3 - System biology modeling for drug optimization, Marko Zivanovic, Nenad Filipovic.- Chapter 4 - Artificial intelligence approach for medical image processing, Tijana Sustersic, Nenad Filipovic.-Chapter 5 - Pharmacokinetic and AI modeling, Lazar Velicki, Nenad Filipovic.- Chapter 6 - Molecular micro modeling of heart muscle, Momcilo Prodanovic, Nenad Filipovic.- Chapter 7 - Use case: Risk stratification of cardiomyopathy disease, Lazar Dasic, Nenad Filipovic.- Chapter 8 - Use case: Surrogate AI model for left ventricle modeling, Bogdan Milicevic, Nenad Filipovic.- Chapter 9 - Use case: Carotid artery plaque modeling, Andjela Blagojevic, Nenad Filipovic.- Chapter 10 - Use case: Stent deployment for coronary artery, Miljan Milosevic, Nenad Filipovic.- Chapter 11 - Use case: Balloon deployment for peripheral arteries. Aleksandra Vulovic, Nenad Filipovic.- Chapter 12 - Use case: Aorta stenosis modeling, Smiljana Tomasevic, Nenad Filipovic.- Chapter 13 - Use case: Stent biodegradation modeling, Dalibor Nikolic, Nenad Filipovic.

This book covers in silico clinical trials of cardiovascular disease using a finite element and machine learning approach. Part I describes the fundamentals as well as the latest developments in the field: finite element modeling, system biology modeling for drug optimization, artificial intelligence approach for medical image processing, as well as pharmacokinetic and AI modeling. Part II provides use cases to describe how in silico clinical trials of cardiovascular disease are applied to specific cardiovascular diseases: carotid artery plaque modeling, aorta stenosis modeling, stent biodegradation modeling, surrogate AI model for left ventricle modeling, and more. This book is geared toward upper-level undergraduate and graduate students as well as for researchers in the domains of bioengineering, biomechanics, biomedical engineering and medicine.

Includes patient-specific models as well as easy-to-use parametric models Describes conclusion from large-scale virtual cardiovascular disease studies Covers system biology modeling for drug optimization as well as drug databases for cardiovascular disease

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