I. Gasotransmitters: Past, Present, and Future.- 1 The Evolution of Gasotransmitter Biology and Medicine: From Atmospheric Toxic Gases to Endogenous Gaseous Signaling Molecules.- 2 Interactions Between Gasotransmitters.- II. The Emergence of the First Gasotransmitter: Nitric Oxide.- 3 Nitric Oxide: Synthesis and Metabolism, Tissue Stores, and the Relationship of Endothelium-Derived Nitric Oxide to Endothelium-Dependent Hyperpolarization.- 4 Chemical Interaction of Nitric Oxide With Protein Thiols: S-Nitrosylation Signaling.- 5 Nitric Oxide and Adenosine Triphosphate-Sensitive Potassium Channels: Their Different Properties But Analogous Effects on Cellular Protection.- 6 Interactions of Nitric Oxide and Related Radical Species With KCa Channels.- 7 Nitric Oxide and Voltage-Gated Ca2+ Channels.- 8 Interactions of Nitric Oxide and Cardiac Ion Channels.- 9 S-Nitrosylation of Cyclic Nucleotide-Gated Channels.- III. Story of a Silent Killer: The Resurgence of Carbon Monoxide as the Second Gasotransmitter.- 10 Synthesis and Metabolism of Carbon Monoxide.- 11 Interaction of Carbon Monoxide With K+ Channels in Vascular Smooth Muscle Cells.- 12 Modulation of Multiple Types of Ion Channels by Carbon Monoxide in Nonvascular Tissues and Cells.- 13 The Molecular Mechanisms Underlying the Effects of Carbon Monoxide on Calcium-Activated K+ Channels.- 14 Carbon Monoxide and Signal Transduction Pathways.- 15 Carbon Monoxide-Induced Alterations in the Expression of KCa Channels in Pulmonary Artery Smooth Muscle Cells.- IV. Gas of the Rotten Egg: Hydrogen Sulfide as the Third Gasotransmitter.- 16 Hydrogen Sulfide Production and Metabolism in Mammalian Tissues.- 17 Toxicological and Environmental Impacts of Hydrogen Sulfide.- 18 Hydrogen Sulfide and the Regulation of Neuronal Activities.- 19 The Role of Hydrogen Sulfide as an Endogenous Vasorelaxant Factor.- 20 Hydrogen Sulfide and Visceral Smooth Muscle Contractility.- 21 Interaction of Hydrogen Sulfide and Adenosine Triphosphate-Sensitive Potassium Channels in Vascular Smooth Muscle Cells.- V. Gasotransmitters, Other Gaseous Molecules, and Cell Metabolism.- 22 Gasotransmitters as a Novel Class of Metabolic Regulators: Nitric Oxide, Carbon Monoxide, and Nitrous Oxide.

Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. Included in the array of different mechanisms for the interaction of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and altered cellular redox status. The authors also offer guidance and suggestions for exploring and further characterizing other still unknown gasotransmitters. Authoritative and comprehensive, Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine offers clinical scientists and physicians not only a deeper understanding, but also a cutting-edge review, of the critically important field of gasotransmitter biology and medicine.

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