This book provides readers with a comprehensive review of severe asthma in children and adolescents, covering epidemiology, genetics, risk factors, co-morbidities, clinical presentation, diagnosis and treatment.

 PART I  GENERAL OVERVIEW.-Chapter 1.The Epidemiology of Severe Childhood Asthma.-Chapter 2.Special Considerations in Preschool Age.-PART II DIAGNOSIS OF SEVERE ASTHMA.-Chapter 3.Confirming the Diagnosis of Severe Asthma in Children.-Chapter 4. Asthma Plus—Comorbidities in Severe Childhood Asthma.-PART III MANAGEMENT OF SEVERE ASTHMA.-Chapter 5.A Multidisciplinary Approach to Managing Difficult to Treat Asthma in Children.-Chapter 6. Stepwise Pharmacological Approach to Severe Childhood Asthma.-Chapter 7. Immunotherapy and Immunomodulators.-Chapter 8. Special Considerations for the Management of Severe Preschool Wheeze.-Chapter 9. Management of Medication Side Effects and Complications.-Chapter 10. Management of Acute, Severe, and Life-Threatening Exacerbations.- 11.-PART IV CURRENT AND FUTURE RESEARCH.-Chapter 12.Basic Mechanisms Underpinning Severe Childhood Asthma.-Chapter 13.Severe Asthma—Clinical Studies and Clinical Trials in Children.-Chapter 14.Potential Therapeutic Options for Severe Asthma in Children: Lessons from Adult Trials.-Chapter 15.Genomics and Pharmacogenomics of Severe Childhood Asthma.-Chapter 16. Future Directions in Severe Childhood Asthma.

This book provides readers with a comprehensive review of severe asthma in children and adolescents, covering epidemiology, genetics, risk factors, co-morbidities, clinical presentation, diagnosis and treatment. Written by leaders in the field, chapter discussions draw on the mechanisms driving the disease, genetics, multidisciplinary approaches, and immunomodulators, and other important aspects in the management of the disease. 

Severe Asthma in Children and Adolescents: Mechanisms and Management is designed to be a practical guide, opening with an introduction on the epidemiology of severe childhood asthma, as well as a discussion of special considerations of the disease unique to the preschool-aged patient.  The distinctions between the diagnosis and management of asthma in young children of various ages, and specific approaches for the adolescent with severe asthma, including the transition into adult care are then addressed. Finally, the book closes with a discussion on the current state and future avenues for severe asthma research. 

Severe Asthma in Children and Adolescents is an indispensable reference for the healthcare professional, for basic and translational researchers, as well as for students, residents and fellows.

Thoroughly explores and considers the impact of age, special considerations in young children, issues in adherence, and the importance of a formal approach in the transition to adult care for adolescent patients with severe asthma Written by experts in the field, this book focuses on multidisciplinary management of severe asthma, including information updated current research and future directions in the field Addresses severe asthma in children as a heterogeneous and often difficult-to-treat disorder, thereby approaching the subject in consideration to the disproportionate amount of asthma related healthcare expenditures

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