This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature.

Multiorgan dysfunction syndrome (MODS): What is new?.- MODS scores. Which should I use?.- Why guidelines require reform.- PIRO concept and clinical failure.- PIRO-based approach for sepsis in immunocompromised patients: What's different?.- Intra-abdominal hypertension and MODS.- Assessing renal dysfunction in septic patients.- Monitoring myocardial dysfunction as part of sepsis management.- The lung in multi-organ failure.- Pathogens in severe sepsis. New paradigms for gram positive treatment.- Pathogens in severe sepsis. New paradigms for fungi treatment.- Importance of high creatinine clearance for antibacterial treatment in sepsis.- How do I adjust antimicrobial daily dosage in patients with MODS? A pharmacist’s contribution .- Improving outcomes in sepsis and septic shock: Getting it right the first time.

This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent experts in the field from Europe and beyond offer new insights into risk stratification, severity assessment, and management of critically ill patients with sepsis. The principal focus is on recently developed concepts in infection management and in antibiotic use, bearing in mind that in these patients the pharmacokinetics of antibiotics are altered, affecting renal clearance and requiring dosage adjustments. The significance of the PIRO (predisposing factors, infection, response, organ dysfunction) model in the development of effective treatment strategies is emphasized. This book will be of interest and value to all who are involved in the treatment of, or research into, sepsis and MODS.