Incorporating the newest findings from cell and molecular biology with the fundamentals of internal medicine, this text covers a whole range of disciplines. These include new medicines and treatments emerging from recent molecular approaches.

Part I. Introduction To Molecular Medicine Andrea Ballabio and J. Larry Jameson . Organization of the Human Genome Chromosomes and Genes Sarah H. Elsea and Pragna I. Patel. Recombinant DNA and Genetic Techniques Marcus Grompe Wade Johnson and J. Larry Jameson. Transcriptional Control of Gene Expression Wade Johnson and J. Larry Jameson. Transmission of Human Genetic Disease Peter Kopp and J. Larry Jameson. The Human Genome Project J. Larry Jameson. The Cell Cycle Lynda Q. Nguyen and J. Larry Jameson. Oncogenes and Tumor Suppressor Genes J. Larry Jameson. Molecular Diagnostic Testing C. Sue Richards and Patricia A. Ward. Genetic Counseling Beth A. Fine. Transgenic Mice as Models of Disease T. Rajendra Kumar and Martin M. Matzuk. Part II. Cardiology Anthony Rosenzweig. Molecular Cardiology: An Overview Anthony Rosenzweig. Congenital Heart Disease: Inherited Cardiomyopathies Christine E. Seidman Calum MacRae and J. G. Seidman. Coronary Atherosclerosis Robert E. Gerszten and Anthony Rosenzweig. Endothelium-Derived Nitric Oxide and Control of Vascular Tone Santiago Lamas and Thomas Michel. Hypertension George Koike and Howard J. Jacob. Cardiac Arrhythmias Barry London. Cardiovascular Gene Therapy Giuseppe Vassalli and David A. Dichek. Part II. Hematology Swee Lay Thein. Hematopoiesis: Growth Factors and Mechanisms of Regulation Andrew Haynes and Nigel Russell. Disorders of Hemoglobin Structure and Synthesis Swee Lay Thein and Jacques Rochette.Disorders of the Red Cell Membrane Jean Delaunay. Red Cell Enzymopathies Lucio Luzzatto and Rosario Notaro. Coagulation Disorders Martina Daly Anne Goodeve Peter Winship and Ian Peake. Thrombotic Disorders Robin J. Olds David A. Lane and Swee Lay Thein. Paroxysomal Nocuturnal Hemoglobinuria Bruno Rotoli and Khedoudja Nafa. Leukemias Jeffrey E. Rubnitz and Ching-Hon Pui . Lymphomas Finbarr E. Cotter . Part IV. Immnology Ralph C. Williams Jr. Regulation of Humoral Immunity Ralph C. Williams Jr. Molecular Regulation of Cellular Immunity Eric Sobel. Cytokines William L. Lowe Jr. and Barbara A. da Silva. The HLA Complex Robert W. Karr. Inherited Immune Deficiency Richard Hong. Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (AIDS) John W. Sleasman and Maureen M. Goodenow. Autoimmune Diseases N. Lawrence Edwards.Allergic Diseases: Asthma as a Model Susan M. MacDonald. Part V. Pulmonolgy Michael J. Holtzman. Asthma Michael J. Holtzman Dwight C. Look Michael F. Iademarco Douglas C. Dean Deepak Sampath and Mario Castro. Cystic Fibrosis Daniel B. Rosenbluth and Steven L. Brody. Pulmonary Emphysema Steven D. Shapiro and Robert M. Senior Surfactant Deficiency Jeffrey A. Whitsett and Timothy E. Weaver. Lung Cancer: The Role of Tumor Suppressor Genes Steven Jay Weintraub. Part VI. Gastroenterology James C. Reynolds. Hepatology Piet C. de Groen and Nicholas F. LaRusso. Inherited Liver Disease Juan Ruiz and George Y. Wu.Viral Hepatitis and Liver Disease Sanjeev Gupta and Michael Ott. Pancreatic Exocrine Dysfunction David Whitcomb and Jonathan Cohn. Small- and Large-Bowel Dysfunction Deborah C. Rubin. Part VII. Endrocrinology Michael J. McPhaul md and J. Larry Jameson. Mechanisms of Hormone Action William L. Lowe Jr. Richard G. Pestell Laird D. Madison and J. Larry Jameson. Diabetes Mellitus William L. Lowe Jr. Pituitary Function and Neoplasia Shlomo Melmed. Growth Hormone Deficiency Disorders Joy D. Cogan and John A. Phillips III. Thyroid Disorders Peter Kopp and J. Larry Jameson. Disorders of the Parathyroid Gland Andrew Arnold and Andrew F. Stewart. Congenital Adrenal Hyperplasia Robert C. Wilson and Maria I. New. Adrenal Diseases Constantine A. Stratakis and George P. Chrousos. Multiple Endocrine Neoplasia Type 2 Robert F. Gagel Sarah Shefelbine and Gilbert Cote. Molecular Mechanisms of Hypoglycemia Associated with Increased Insulin Production Pamela M. Thomas Gilbert J. Cote and Robert F. Gagel. Regulation of Reproduction Michael J. McPhaul. Disorders of Sex Determination and Differentiation Charmian A. Quigley. Sex Chromosome Disorders Andrew R. Zinn. Disorders of Pubertal Development Karen D. Bradshaw and Charmian A. Quigley. Defects of Androgen Action Michael J. McPhaul. Testicular Diseases Marco Marcelli. Ovarian Diseases Elizabeth A. McGee and Nicholas A. Cataldo. Breast Cancer Melora D. Berardo D. Craig Allred and Peter O'Connell. Part VIII. Nephrology. Dennis Ausiello. Renal Development Vikas P. Sukhatme. Mechanisms of Leukocyte Extravasation M. Amin Arnaout. Ischemic Acute Renal Failure Joseph V. Bonventre. Potassium Secretory Channels in the Kidney Steven C. Hebert. Alport Syndrome Karl Tryggvason and Pirkko Heikkil". Nephrogenic Diabetes Insipidus Dennis Brown and Dennis A. Ausiello. Polycystic Kidney Disease Gregory G. Germino and Luiz F. Onuchic. Renal Neoplasms: Wilms' Tumor and Renal-Cell Carcinoma Kim E. Nichols and Daniel A. Haber. Part IX. DermatologyThomasS. Kupper. Congenital Diseases of Cutaneous Tissues. Selected Epidermal Gene Mutations. Introduction to Selected Epidermal Gene Mutations Angela M. Christiano Daniel B. Dubin and Thomas S. Kupper. Epidermolysis Bullosa SimplexYiu-mo Chan and Elaine Fuchs. Epidermolytic Hyperkeratosis John J. DiGiovanna Sherri J. Bale and Peter M. Steinert. Mosaicism and Epidermal Nevi Amy S. Paller. Darier's Disease and Hailey-Hailey Disease Lowell A. Goldsmith and Ervin Epstein Jr. Junctional Forms of Epidermolysis Bullosa Angela M. Christiano and Jouni Uitto. The Dystrophic Forms of Epidermolysis Bullosa Jouni Uitto and Angela M. Christiano . Genetic Mutations that Predispose to Cancer. Oculocutaneous Albinism Jean L. Bolognia. Basal Cell Nevus Syndrome Ervin Epstein Jr. Xeroderma Pigmentosa and Related Disorders W. Clark Lambert Hon-Reen Kuo and Muriel W. Lambert. The Skin as a Vehicle for Gene Therapy Soosan Ghazizadeh Tadeusz M. Kolodka and Lorne B. Taichman. Acquired Diseases of Cutaneous Tissues. Acquired Diseases of Cutaneous Tissues: Introduction Thomas S. Kupper. Basal- and Squamous-Cell Carcinoma Paul Nghiem and Thomas S. Kupper. Melanoma Genetics Daniel B. Dubin and Saumyen Sarkar. Psoriasis James T. Elder and John J. Voorhees. Atopic Dermatitis and Atopy Donald Y. M. Leung and Larry Borish. Pemphigus Foliaceus and Pemphigus Vulgaris Janet A. Fairley Xiang Ding George J. Giudice and Luis A. Diaz. Bullous Pemphigoid Cicatrical Pemphigoid and Pemphigoid Gestationis Grant J. Anhalt and Diya F. Mutasim. Cutaneous Lupus Erythematosus Richard D. Sontheimer. Scleroderma (Systemic Sclerosis) and Morphea Edwin A. Smith and E. Carwile LeRoy. Part X. Musculoskeletal Laurence Kedes. Muscle Development and Differentiation Eric N. Olson. Skeletal Muscle Structure and Function Henry F. Epstein. Muscular Dystrophies Eric P. Hoffman. Rhabdomyosarcomas Stephen J. Tapscott. Part XI. Neurology Joseph B. Martin. Molecular Neurobiology Joseph B. Martin and Frank M. Longo. Huntington's Disease Marcy E. MacDonald. Molecular Genetics of Alzheimer's Disease P. H. St. George-Hyslop. Amyotropic Lateral Sclerosis and Related Motor Neuron Diseases Meret E. Cudkowicz and Robert H. Brown Jr. Spinocerebellar Ataxia and Other Disorders of Trinucleotide Repeats Huda Y. Zoghbi. Charcot-Marie-Tooth Disease and Related Peripheral Neuropathies James R. Lupski. Molecular and Genetic Basis of Prion Diseases Stanley B. Prusiner. Genetic Basis of Mitochondrial Disease Donald R. Johns. Malignant Hyperthermia and Central Core Disease David H. MacLennan and Beverley A. Britt. Retinoblastoma: A Current Review Joan M. O'Brien. Neurofibromatosis: Type 1 and Type 2 Jaime O. Claudio and Guy A. Rouleau. Brain Tumors Mark A. Israel. Part XII. Psychiatry Charles B. Nemeroff. Molecular Mechanisms and Regulating Behavior Paul M. Plotsky and Charles B. Nemeroff. Schizophrenia Ming T. Tsuang and Stephen V. Faraone. Affective Disorders Francis J. McMahon and J. Raymond DePaulo Jr. Alcoholism Eric J. Devor and Arthur Falek. Part XIII. Genetic Basis of Congentical Malformations Ethylin Wang Jabs. Waardenburg Syndrome Andrew P. Read. Greig Cephalopolysyndactyly Syndrome and Limb Disorders Karl-Heinz Grzeschik. Fibroblast Growth Factor Receptor-Related Skeletal Disorders: Craniosynostosis and Dwarfism Syndromes Maximilian Muenke Clair A. Francomano M. Michael Cohen Jr. and Ethylin Wang Jabs. Aarskog-Scott Syndrome Jerome L. Gorski. Beckwith-Wiedemann Syndrome Ellen R. Elias Michael R. DeBaun and Andrew P. Feinberg. Prader-Willi and Angelman Syndromes Robert D. Nicholls. Fragile X Syndrome David L. Nelson. Down Syndrome Stylianos E. Antonarakis. The 22q11 Deletion: DiGeorge and Velocardiofacial Syndrome Deborah A. Driscoll and Beverly S. Emanuel. Orofacial Clefting Jacqueline T. Hecht and Susan H. Blanton. Molecular Genetics of Hearing Disorders William J. Kimberling. Index.

Winner of the Book of the Year Award from Doody's Health Science Book Review Journal The selection of topics, the ability of the contributors to present complex topics in a clear, concise manner, and the format should all contribute to making this book the standard text and reference in its field. It should be in the collection of every medical library and on the bookshelf of every physician interested in keeping up with the transformation of medicine by molecular genetics. 5 Stars - Doody's Health Science Book Review Journal. "...bridge[s] the current gap between basic science and the bedside. It will thus be useful to researchers and clinicians alike. With more than 100 chapters covering a wide variety of topics, its distinguished cohort of section editors, and its abundant tables and illustrations, it provides an accessible and much needed manual to the present and the future of molecular genetics." - Francis S. Collins, MD, PhD "...a first-class reference textbook. The format of this book is easy to follow and is relevant to the way in which medicine is currently practiced. Its division into the traditional disciplines of medicine makes it easy to identify how molecular developments have enhanced our medical knowledge, diagnostic potentials and therapeutic options...The editor-in-chief, his section editors and the contributing authors should all be congratulated on a superb job." - Molecular Medicine Today Because molecular medicine has already started to become an integral part of medical practice, there is a growing need to integrate it into the medical school curriculum and medical education in general. Principles of Molecular Medicine is well suited to serving this purpose...closing the gap between basic science and the bedside. The book is organized according to organ systems and comprises more than 120 chapters, each written by outstanding specialists...The various facets of human hereditary disorders, including genetic counseling and molecular diagnostic testing, are clearly and comprehensively presented...the book is well written and attractive...[and] is a valuable resource that will certainly appeal to clinicians, researchers, teachers, and students alike. It will also be of value to those involved in a particular area of molecular medicine who need a reference manual in which to find information on aspects of the field in which they are less familiar...a valuable reference for anyone with an interest in the achievements and the potential of molecular medicine. - Michael Goosens, MD review in the May 20, 1999 issue of the New England Journal of Medicine