The “Pathophysiology of Cancer: An Interdisciplinary Approach” is the twenty-two volume of the “Interdisciplinary Cancer Research” series and a comprehensive volume on the pathophysiology of cancer. The volume starts with a few chapters on the risk of cancer development and carcinogenesis, including mitochondrial energy metabolism in carcinogenesis and the role of mitochondrial DNA mutations in cancer development. The obesity epidemic and cancer risk, urban road dust, genotoxicity, aberrant glycosylation, melatonin, and matrix metalloproteinases as players in cancer development and progression are explained in other chapters. The subsequent chapters discuss vascular endothelium, extracellular vesicles and extracellular matrix, circulating tumor cells, cancer-associated programmed-cell death, and epithelial-to-mesenchymal transition in cancer. Importance of antioxidants, decoding metabolic changes and effects of secondary metabolites in cancer therapy are the subjects of the concluding chapters. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for those who wish to have an update on the pathophysiology of cancer.