Written by an established, comprehensive, multidisciplinary focused, internationally-recognized team, the sixth edition has been fully revised and brought up to date with the inclusion of recent developments in the speciality, to ensure that it retains its reputation as the definitive reference on palliative care.

Section 1: The worldwide status of palliative care 1.1: Carlos Centeno, Sheila Payne, and Eduardo Garralda: International progress in the development of palliative care 1.2: Lukas Radbruch and Liliana De Lima: Essential medicines for palliative care 1.3: Frank Brennan and Liz Gwyther: Human rights issues 1.4: Stephen R. Connor: Policy in palliative care Section 2: The challenge of palliative medicine 2.1: Russell K. Portenoy: Building definitional consensus in palliative care 2.2: Nathan I. Cherny and Russell K. Portenoy: Core concepts in palliative care 2.3: Davinia Seah, David Marco, Jennifer Philip, and Megan B. Sands: The epidemiology of death and symptoms: planning for population-based palliative care 2.4: Barry Laird, Erna Haraldsdottir, and Charlie Hall: Barriers to the delivery of palliative care 2.5: Jonathan Koffman and Natalia Calanzani: Ethnic and cultural aspects of palliative and end of life care 2.6: Peter S. Hall, Katharina Diernberger, and Liz Grant: Health economics for palliative care Section 3: Service delivery issues in palliative care 3.1: Breffni Hannon, Stein Kaasa, and Camilla Zimmermann: Specialist palliative care along the trajectory of illness: issues in the early integration of palliative care 3.2: Irene J. Higginson: Palliative care delivery models 3.3: Sharon Einav, Nathan I. Cherny, and J. Randall Curtis: Palliative medicine in the intensive care unit 3.4: Naomi George and Corita Grudzen: Palliative care in the emergency department 3.5: Jane Phillips and Annmarie Hosie: Palliative care in the nursing home Section 4: Healthcare professionals in palliative care 4.1: Dagny Faksvåg Haugen, Friedemann Nauck, and Deborah Witt Sherman: The core team and the extended team 4.2: Nathan I. Cherny, Batsheva Werman, and Michael Kearney: Burnout, compassion fatigue, and moral distress in palliative care 4.3: Betty R. Ferrell, Polly Mazanec, Pam Malloy, and Rose Virani: Nursing Education in palliative care 4.4: Terry Altilio, Bridget Sumser, and Nina Laing: Social work in palliative care 4.5: George Handzo and Christina Puchalski: The role of the chaplain in palliative care 4.6: Maria Denise Pessoa Silva, Fiona Rolls, Lynne White, Tamsin Longley, Jane Murphy, and Jill Cooper: Occupational therapy in palliative care 4.7: Nigel Hartley: The role of the creative arts in palliative care 4.8: Samantha Cushen and Aoife Ryan: The role of the dietitian in palliative care 4.9: Lucy Fettes and Matthew Maddocks: Physiotherapy in palliative care 4.10: Tim Luckett and Katherine L.P. Reid: Speech and language therapy in palliative care 4.11: E. Alessandra Strada: Clinical psychology in palliative care 4.12: Ebtesam Ahmed: The contribution of the clinical pharmacist in palliative care 4.13: Andrew M. Cole: Medical rehabilitation and the palliative care patient Section 5: Communication and palliative medicine 5.1: Thomas W. LeBlanc and James Tulsky: Communication with the patient and family 5.2: Susan D. Block: Practical considerations including difficult conversations 5.3: Judith Rietjens, Ida Korfage, and Jane Seymour: Advance care planning Section 6: Family and caregiver issues 6.1: Carrie Lethborg and David W. Kissane: Family dynamics in the context of serious illness 6.2: Rinat Nissim, Sarah Hales, and Gary Rodin: Caregiver burden and distress Section 7: Pain 7.1: Lucy N. Wyld, Clare Rayment, and Mike I. Bennett: Definition and assessment of chronic pain in advanced disease 7.2: Anthony H. Dickenson and Richard Gordon-Williams: Pathophysiology of pain in cancer and other terminal illnesses 7.3: Nathan I. Cherny: Acute cancer pain syndromes 7.4: Nathan I. Cherny: Chronic cancer pain syndromes 7.5: Ruth Miles, Steven Wanklyn, and Joy Ross: Principles of drug therapy 7.6: Nathan I. Cherny and Marie T. Fallon: Opioid therapy: optimizing analgesic outcomes 7.7: Joseph V. Pergolizzi, Jr., Jo Ann LeQuang, Flaminia Coluzzi, Dean Mariano, Andrew Nicolaou, and Christopher Gharibo: Opioid therapy: managing risks of abuse, addiction, and diversion 7.8: Per Sjøgren, Frank Elsner, and Stein Kaasa: Non-opioid analgesics 7.9: Russell K. Portenoy, Ebtesam Ahmed, and Mona Patel: Adjuvant analgesics: principles of use 7.10: Robert A. Swarm, Menelaos Karanikolas, Lesley K. Rao, and Rajiv K. Shah: Interventional approaches for chronic pain 7.11: Helena Knotkova: Neurostimulation in pain management 7.12: Joseph Winger, Carolyn E. Keeler, and Francis Keefe: Behavioral and psychosocial interventions for pain management 7.13: Noah Samuels and Eran Ben-Arye: Integrative medicine therapies in pain management 7.14: Peter Hoskin: Management issues in bone pain 7.15: Lise Ventzel and Nanna Finnerup: Management issues in neuropathic pain 7.16: Victor T. Chang: Management issues in visceral pain 7.17: Judith A. Paice: Management issues in chronic pain following cancer therapy 7.18: Renee McCulloch: Paediatric pain control Section 8: Gastrointestinal symptoms and disorders 8.1: Katherine Clark: Dysphagia, dyspepsia, and hiccups 8.2: Saskie Dorman: Nausea and vomiting 8.3: Philip J. Larkin: Constipation and diarrhoea 8.4: Alexandra Shingina and Anne M. Larson: Jaundice, ascites, and encephalopathy 8.5: Vickie Baracos and Sharon M. Watanabe: Aetiology, classification, assessment, and treatment of the anorexia-cachexia syndrome 8.6: Jann Arends and Florian Strasser: Parenteral nutrition Section 9: Cardio-respiratory symptoms and disorders 9.1: Miriam J. Johnson and David C. Currow: Breathlessness and other respiratory symptoms in palliative care 9.2: Doris Tse and Kin-Sang Chan: Cough and other pulmonary symptoms Section 10: Skin and oral symptoms and disorders 10.1: Sebastian Probst and Georgina Gethin: Skin problems in palliative care 10.2: Charles P. Tilley, Mei R. Fu, Janet H. Van Cleave, Allison R. Most, and Christopher Comfort: Palliative wound and ostomy care 10.3: Vaughan Keeley: Lymphoedema and oedema of advanced disease 10.4: Andrew N. Davies: Oral care Section 11: Genitourinary symptoms and disorders 11.1: Jennifer G. Rothschild, Noah E. Canvasser, Frederick J. Meyers, and Christopher Evans,: Dysuria, frequency, and bladder spasm 11.2: Noah E. Canvasser, Jennifer G. Rothschild, Frederick J. Meyers, and Christopher P. Evans: Obstructive urinary disorders Section 12: Constitutional symptoms and related disorders 12.1: Sriram Yennurajalingam and Eduardo Bruera: Fatigue 12.2: Lauren Kadwell, Jane Ussher, Emilee Gilbert, Janette Perz, and Amanda Hordern: Sexuality in palliative care: discussing patient sexuality and intimacy in palliative care 12.3: Kyriaki Mystakidou, Efi Parpa, and Eleni Tsilika: Sleep disorders 12.4: Simon Noble, Nicola Pease, and Nicholas Chinn-Yee: Assessment and management of thrombotic complications 12.5: Bill Hulme, Sarah Wilcox, Paul Ashwood, Laura Deacon, Hazel Gilkes, and Victoria Montgomery: Assessment and management of bleeding complications in the medically ill Section 13: Psychiatric and psychological symptoms and disorders 13.1: Tzeela Cohen and Simon Wein: Coping and resilience in palliative medicine 13.2: David W. Kissane: Depression, demoralization, and suicidality 13.3: Kerry A. Sherman and Christopher J. Kilby: Fear, anxiety, and adjustment disorder in palliative care 13.4: Meera Agar, Yesne Alici, Augusto Caraceni, and William Breitbart: Delirium 13.5: David W. Kissane: Bereavement Section 14: Palliative care in cancer 14.1: Nathan I. Cherny and Stein Kaasa: The oncologist s role in delivering palliative care 14.2: Olav Dajani and Karin Jordan: Disease-modifying therapies in advanced cancer-medical treatment 14.3: Peter Hoskin: Radiotherapy in symptom management 14.4: Robert Krouse and Brian Badgwell: The role of general surgery in the palliative care of patients with cancer 14.5: Mohamed Yakoub and John Healey: Orthopaedic surgery in the palliation of cancer 14.6: Eran Ben-Arye and Noah Samuels: Integrative oncology in palliative medicine 14.7: Tarun Sabharwal, Nicos I. Fotiadis, and Andy Adam: Interventional radiology in the palliation of cancer 14.8: Augusto Caraceni, Fabio Simonetti, and Cinzia Martini: Neurological problems in advanced cancer 14.9: Richella Ryan and Ruth Casey: Endocrine and metabolic complications of advanced cancer 14.10: Jason W. Boland and Elaine G. Boland: Malignant Bowel obstruction 14.11: Catriona R. Mayland and Simon N. Rogers: Palliative care issues in head and neck cancers 14.12: Thomas W. LeBlanc and Arjee El-Jawahri: Palliative care issues in populations with haematological malignancies 14.13: Nancy Zhu and Cynthia Wu: Anaemia, cytopenias, and thrombosis in palliative medicine Section 15: Issues in populations with non-cancer illnesses 15.1: Meera Pahuja and Peter Selwyn: HIV/AIDS 15.2: Natasha Smallwood and Nicole Goh: Advanced diseases of the lung 15.3: Steve Pantilat, Patricia Davidson, and Mitch Psotka: Advanced heart disease 15.4: Eric Widera, Shaida Talebreza, and Rachelle E. Bernacki: Dementia 15.5: Stefan Lorenzl and Raymond Voltz: Neurological disorders other than dementia 15.6: Arpan Patel and Anne Walling: Palliative care and end-stage liver disease 15.7: Fliss E.M. Murtagh: End-stage kidney disease 15.8: Anne Wilkinson and Marianne Matzo: Palliative care in catastrophic disasters and humanitarian crises Section 16: Issues of the very young and the very old 16.1: Erna Haraldsdottir and Sally Paul: Involving children and families when someone important is dying or has died 16.2: Myra Bluebond-Langner, Richard W. Langner, and Ignasi Clemente: Care of children with advanced illness 16.3: Meera Agar and Jane Phillips: Palliative medicine and care of the elderly Section 17: Spiritual issues in palliative medicine 17.1: Susan McClement, Genevieve Thompson, and Jamie Penner: Spiritual issues in palliative medicine 17.2: Yvan Beaussant, Alexandra Nichipor, and Tracy A. Balboni: Integration of spiritual care into palliative care service delivery models Section 18: The terminal phase 18.1: Christian T. Sinclair: Predicting survival in patients with advanced disease 18.2: David Hui and Masanori Mori: Physiology of dying 18.3: Judith Lacey and Nathan I. Cherny: Management of the actively dying patient Section 19: Ethical issues 19.1: Robert C. Macauley: Practical bioethics in the care of patients with advanced illness 19.2: Alexander A. Kon: Requests for futile or inappropriate interventions near the end of life 19.3: Nathan I. Cherny: Autonomy and shared decision making in a multi-cultural world 19.4: Linda Emanuel, Rebecca Johnson, and Lara Boyken: Truth-telling and consent 19.5: Richard D.W. Hain: Ethics in paediatric palliative care 19.6: Lars Johan Materstvedt: Ethical issues in physician aid-in-dying 19.7: Danielle Ko, Hannah Evans-Barns, and Craig Blinderman: Withholding and withdrawing life-sustaining treatment (including artificial nutrition and hydration) 19.8: Eric L. Krakauer: Medical and ethical considerations in palliative sedation at the end of life Section 20: Assessment tools and Informatics 20.1: Afaf Girgis, Amy Waller, and Breanne Hobden: Palliative care needs assessment tools 20.2: Jennifer Tieman and David C. Currow: Informatics and literature search 20.3: Madeline Li, Tracy A. Balboni, Rinat Nissim, and Gary Rodin: Validated assessment tools for psychological, spiritual, and family issues Section 21: Teaching and training in palliative medicine 21.1: Karen Forbes and Jane Gibbins: Physicians 21.2: Geana Paula Kurita and Philip J. Larkin: Nurses 21.3: Myra Glajchen, George Handzo, and Ebtesam Ahmed: Teaching and training in palliative social work, chaplaincy, and pharmacy Section 22: Research in palliative medicine 22.1: Marianne J. Hjermstad and Stein Kaasa: Research in palliative care 22.2: Miriam J. Johnson and David C. Currow: The principles of evidence-based medicine 22.3: Pål Klepstad and Stein Kaasa: Understanding clinical trials in palliative care research 22.4: Kate Flemming: Qualitative research 22.5: David K. Kissane, Christopher H. Grossman, and Clare O'Callaghan: Research into psychosocial issues 22.6: Tyler Tate and David Casarett: Ethical issues in palliative care research 22.7: Jon Håvard Loge and Stein Kaasa: Quality of life and patient-reported outcome measures 22.8: Tinne Smets and Luc Deliens: Health services research in palliative and end-of-life care 22.9: Irene J. Higginson and Mevhibe B. Hocaoglu: Clinical audit in palliative medicine

Nathan I. Cherny is Norman Levan Chair of Humanistic Medicine at Shaare Zedek Medical Center and Associate Professor of Medicine at Ben Gurion University, Israel. In 2015 he was awarded the ESMO (European Society of Medical Oncology) Award for his contributions to the development of oncology in Europe, and in 2016 was the recipient of the EAPC/EJPC (European Association of Palliative Care/ European Journal of Palliative Care) Palliative Care Policy Development Award. Nathan has diverse research interests including opioid responsiveness of neuropathic pain, opioid rotation, opioid side effects and their management, cancer pain syndromes, suffering, palliative sedation, communication issues in oncology and palliative care, bioethics, and public health. He teaches in the Hebrew University Medical School and runs courses in communication and palliative medicine. Nathan has edited five books and has published over 120 peer reviewed papers and has made numerous invited lectures worldwide. Marie T. Fallon is the St Columba's Hospice Chair of Palliative Medicine at the University of Edinburgh, Honorary Consultant in Palliative Care at the Western General Hospital in Edinburgh and leads the Edinburgh Palliative and Supportive Care group (EpaS). Marie serves as Chief Investigator for EpaS on a large portfolio of clinical studies spanning investigator-led randomized controlled trials examining improved management of cancer-induced bone pain, neuropathic pain, and institutionalisation of pain assessment. Marie is also the lead in an international programme of RCTs in cannabinoids in cancer-related pain and has led the development of studies using fMRI in Edinburgh, UK. Stein Kaasa is Professor of Palliative Medicine at the Institute of Cancer Research and Molecular Medicine at the Norwegian University of Science and Technology (NTNU), Norway. Stein specialises in medical oncology, radiotherapy, and palliative medicine. In 1993, he was appointed as the first professor in palliative medicine in Scandinavia and he was one of the founders of the palliative care unit in Trondheim and founder of the European Palliative Care Research Centre (PRC). He has been president of EAPC, the coordinator for a large EU-funded project, and is at present involved in several research collaborative and international partnerships on research and policy development. Stein has been an important advocate for evidence-based practice and has worked extensively to get palliative care research on the global agenda. Stein is also Director of the PRC and Chair of the European Association for Palliative Care Research Network and has published more than 450 articles and book chapters. Russell K. Portenoy is Executive Director and Chief Medical Officer of the MJHS Institute for Innovation in Palliative Care and is Professor of Neurology and Family and Social Medicine at the Albert Einstein College of Medicine, New York. Prior to joining MJHS, he was founding Chairman of the Department of Pain Medicine and Palliative Care and the Gerald J. Friedman Chair in Pain Medicine and Palliative Care at Mount Sinai Beth Israel Medical Center. Russell is Past President of both the American Academy of Hospice and Palliative Medicine and the American Pain Society. He previously chaired the American Board of Hospice and Palliative Medicine. Russell is recipient of the Lifetime Achievement Award, the National Leadership Award of the American Academy of Hospice and Palliative Medicine, the Wilbert Fordyce Award for Lifetime Excellence in Clinical Investigation, the Distinguished Service Award from the American Pain Society, and the Founder's Award by the American Academy of Pain Medicine. David C. Currow is Professor of Palliative Medicine at University of Technology Sydney, the Matthew Flinders Distinguished Professor of Palliative and Supportive Care, Flinders University and Associate Director (Research) at the Wolfson Palliative Care Research Centre, University of Hull, UK. Research includes clinical trials and use of large datasets to understand better the impact of life-limiting illnesses on patients and caregivers. Research into chronic breathlessness is a particular area of interest. He is the principal investigator for the Australian national Palliative Care Clinical Studies Collaborative (PaCCSC) and is a foundation partner in the Australian national Palliative Care Outcomes Collaborative (PCOC), an initiative to improve palliative care clinical outcomes through point-of-care data collection.

New in paperback edition of the hugely successful award winning Oxford Textbook of Palliative Medicine, which has gained a reputation as the definitive guide to the field Five international editors guarantee a truly global perspective Over 100 chapters dealing with all aspects of this rapidly developing specialty Rigorously updated to offer a truly global perspective, highlighting the best current evidence-based practices, and collective wisdom from more than 200 experts around the world