A detailed look at the neural and biological mechanisms of psychedelic use• Examines the main pharmacological properties of psychedelic substances, including LSD, DMT, psilocybin, ayahuasca, mescaline, ketamine, ibogaine, salvia, and MDMA• Explains the physiological mechanisms behind visionary effects, including what is happening in the brain and how each psychedelic is processed by the body• Shares safe strategies for using psychedelics, including harm-reduction techniques, and looks at where the future of psychedelic therapies is likely to goWith the widespread legalization of marijuana and the increasing use of psychoactives in controlled therapy settings, further research and understanding of psychedelics is now possible. Yet while individual accounts of their use abound, exactly what’s happening to the brain and body when using these substances is still not widely understood.Longtime pharmacological researcher Genís Ona presents a comprehensive look at the main pharmacological properties of psychedelic substances, including LSD, DMT, psilocybin, ayahuasca, mescaline, ketamine, ibogaine, salvia, tropane alkaloids, and MDMA. Exploring how psychedelics work within the brain, Ona shares results from his extensive research to reveal the physiological mechanisms that allow these molecules to have their visionary effects, explaining what is happening at the receptor level as well as the “cascade” effects that differ from substance to substance. He examines how the body processes each substance, describing how each psychedelic is released, absorbed, distributed, metabolized, and eliminated. He also details possible dangerous interactions between these substances and other drugs as well as their potential toxicity.Although his main focus is the biological and neurological effects of psychedelics, Ona also explores the mystical and spiritual dimension of psychedelic use, particularly as practiced in Indigenous traditions, showing how they enable access to a profound spiritual territory. He shares safe strategies for using psychedelics and looks at where the future of psychedelic therapies is likely to go, with an emphasis on ensuring that traditional knowledge is respected, honored, and protected.
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A detailed look at the neural and biological mechanisms of psychedelic use
Foreword by José Carlos Bouso, Ph.D.Preface1 Brief Introduction to PharmacologyEtymological OriginsMain Pharmacological ConceptsNervous System • Neurons, Synapses,and Action Potentials • Pharmacokinetics andPharmacodynamics • Neurotransmitters • Receptors •Modifying Receptor FunctionWhy Psychedelic Pharmacology?Pharmacology and ComplexityReferences for Further Study2 Pharmacological Classification of the MainPsychedelic Drugs: Structures and Major GroupsSimple Tryptamines, including Psilocybinand DMTErgolamines, including LSDPhenethylamines, including Mescaline and MDMANMDA Receptor Antagonists, including KetamineNew TryptaminesAtypical PsychedelicsTabernanthe iboga • Salvia divinorum •Datura stramoniumReferences for Further Study3 Biological Targets of Psychedelic DrugsSimple Tryptamine TargetsPsilocybin • DMT and AyahuascaErgolamine TargetsLSD • LSAPhenethylamine TargetsMescaline • MDMATargets of NMDA Receptor Antagonists,including KetamineTargets of New TryptaminesTargets of Atypical PsychedelicsIbogaine/Noribogaine • Salvinorin-A •Datura stramoniumReferences for Further Study4 Characteristic Aspects of Psychedelic PharmacologyPHARMACOKINETICSInitial Phases of the Processing of PsychedelicsRelease • Absorption • DistributionMetabolismMetabolism and Aging •Main Centers and Enzymes Responsible for MetabolismRelevant Aspects in the Metabolismof Psychedelic DrugsPsilocybin • DMT/Ayahuasca • LSD • MDMA • Mescaline •Ketamine • Ibogaine/Noribogaine • Salvinorin-A •Tropane AlkaloidsEliminationPHARMACODYNAMICSTherapeutic Effects of PsychedelicsAntidepressant, Anti-inflammatory, and NeuroprotectiveEffects • Therapeutic Effects of Atypical Psychedelics •Increased Neuroplasticity • Neurological Evidence ofPsychedelics’ Therapeutic Effects • Hormonal Effects •Psychological EffectsMicrodosing Psychedelics as an Emerging TrendAdverse Effects in the Therapeutic Use of PsychedelicsToxicity • Studying the Safety of Psychedelics • Health RisksWhen Using Psychedelic Drugs TherapeuticallyPsychoactive Effects of PsychedelicsData on Psychedelics' Psychoactive EffectsToleranceReferences for Further Study5 Harm Reduction in Your Use of Psychedelic DrugsTake Care of Yourself • Check What You Bought •Don’t Get Creative with Routes of Administration •Keep Hydrated • Don’t Mix • Be Patient6 A Look into the Future: Promises and ChallengesMarketing of Psychedelic TherapiesThe Role of Traditional KnowledgeTo Trip or Not to TripAppendix I: The Legal Status of Psychedelic Drugsaround the WorldAppendix II: GlossaryIndex
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Produktdetaljer
ISBN
9798888500040
Publisert
2024-11-21
Utgave
2. utgave
Utgiver
Vendor
Park Street Press,U.S.
Vekt
429 gr
Høyde
229 mm
Bredde
152 mm
Dybde
20 mm
Aldersnivå
P, 06
Språk
Product language
Engelsk
Format
Product format
Heftet
Antall sider
264
Forfatter
Foreword by