Part I: Alzheimer and his contemporaries 1. Alzheimer’s disease: a fortuitous beginning 2. Alzheimer’s first case 3. Alzheimer’s second case and the naming of Alzheimer’s disease 4. Some early observations of Alzheimer’s contemporaries 5. Early studies on senile dementia and aging 6. The human element References 000 Part II: The dark ages 7. The 1920s and 1930s 8. The 1940s to the 1960s Part III: Beyond plaques and tangles: lewy bodies, vascular disease, and the rise of the acronyms 9. Lewy bodies 10. The role of vascular disease in Alzheimer’s disease neuropathology Atherosclerosis 11. The rise of the acronym References 12. Aging-related neuronal tau 13. Aging and disease-related astrocytic tau 14. TDP-43 in aging and Alzheimer’s disease 15. Argyrophilic grain disease Part IV: Alzheimer’s disease, dementia pugilistica, and the influence of neuropathology 16. Introduction to the traumatic brain injury--neurodegenerative disease dichotomy 17. Punch drunk syndrome: the first 30 years 18. Clinicopathological analysis from the 1950s and 1960s 19. 1970 to 2000: transitioning to an immunohistochemistry--only diagnosis 20. The modern chronic traumatic encephalopathy era 21. Postmortem of punch drunk boxers and chronic traumatic encephalopathy Part V: Familial alzheimer’s disease, down syndrome, and the amyloid cascade hypothesis 22. Familial Alzheimer’s disease and Down syndrome 23. The amyloid cascade hypothesis Part VI: Practical considerations in the diagnosis of alzheimer’s disease and aging 24. Application of consensus criteria 25. The diagnostic process

Detailed discussion and analysis of early Alzheimer’s disease investigators and their findings Detailed discussion and analysis of the often-overlooked literature from the 1920’s to the 1960’s Detailed discussion and analysis of aging-related phenomena currently under study Detailed discussion and analysis of punch-drunk syndrome and the transition to modern understanding of chronic traumatic encephalopathy Detailed discussion and analysis of the pathology of autosomal dominant Alzheimer’s disease and Alzheimer’s disease associated with Down syndrome Practical issues with diagnosing and reporting Alzheimer’s disease and aging-related changes