In this issue of Interventional Cardiology Clinics, guest editor Dr. Thomas Smith brings his considerable expertise to the topic of Multi-Modality Interventional Imaging. Top experts in the field discuss key topics such as tricuspid valve TEER guidance with transesophageal echocardiography and ICE; 4D ICE: the next frontier in structural imaging guidance; multiplanar reconstruction: advanced 3D TEE techniques to guide complex structural procedures; CT procedure planning for transcatheter mitral valve replacement; use of CT for LAAO procedure planning and post-procedure assessment; and more. Contains 10 relevant, practice-oriented topics including 4D ICE guidance of left atrial appendage closure: risks and benefits of forgoing transesophageal echocardiography; CT procedure planning for closure of cardiac and great vessel pseudoaneurysms; multimodality fusion: where does it best fit in to structural heart guidance?; the interventional imager: how do we train the next imagers?; and more. Provides in-depth clinical reviews on multi-modality interventional imaging, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.