Contributors ix Preface to the fourth edition xiii Further reading xv Acknowledgments xvi 1 Beginnings: the molecular pathology of hemoglobin 1David Weatherall 2 Stem cells 21David T. Scadden 3 The genetics of acute myeloid leukemias 37Amy M. Trottier & Carolyn J. Owen 4 Molecular diagnostics and risk assessment in myeloid malignancies 49Christian Scharenberg & Torsten Haferlach 5 Molecular basis of acute lymphoblastic leukemia 59Bela Patel & Fiona Fernando 6 Chronic myeloid leukemia 71Hagop Kantarjian, Jorge Cortes, Elias Jabbour & Susan O’Brien 7 Myeloproliferative neoplasms 87Jyoti Nangalia, Anthony J. Bench, Anthony R. Green & Anna L. Godfrey 8 Lymphoma genetics 101Jennifer L. Crombie, Anthony Letai & John G. Gribben 9 The molecular biology of chronic lymphocytic leukemia 111John G. Gribben 10 The molecular biology of multiple myeloma 121Wee Joo Chng & P. Leif Bergsagel 11 The molecular basis of bone marrow failure syndromes and red cell enzymopathies 131Deena Iskander, Lucio Luzzatto & Anastasios Karadimitris 12 Anemia of chronic disease 155Tomas Ganz 13 The molecular basis of iron metabolism 161Nancy C. Andrews & Tomas Ganz 14 Hemoglobinopathies due to structural mutations 173D. Mark Layton & Steven Okoli 15 Molecular pathogenesis of malaria 193David J. Roberts, Arnab Pain & Chetan E. Chitnis 16 Molecular coagulation and thrombophilia 207Björn Dahlbäck & Andreas Hillarp 17 The molecular basis of hemophilia 221Daniel P. Hart & Paul L.F. Giangrande 18 The molecular basis of von Willebrand disease 235Luciano Baronciani 19 Platelet disorders 251Kenneth J. Clemetson 20 The molecular basis of blood cell alloantigens 267Cristina Navarrete, Louise Tilley, Winnie Chong & Colin J. Brown 21 Functions of blood group antigens 285Jonathan S. Stamler & Marilyn J. Telen 22 Autoimmune hematological disorders 297Drew Provan & John W. Semple 23 Molecular therapeutics in hematology: gene therapy 319William M. McKillop & Jeffrey A. Medin 24 Pharmacogenomics 339Leo Kager & William E. Evans 25 History and development of molecular biology 353Paul Moss 26 Cancer stem cells 363Sara Ali & Dominique Bonnet 27 Molecular basis of transplantation 373Francesco Dazzi & Antonio Galleu Index 389

The new and fully-revised volume of molecular GRIBBEN biological techniques for practicing and trainee hematologists Molecular Hematology is a comprehensive resource for hematologists to increase their understanding of the molecular basis of various blood diseases, their pathogeneses, and current and emerging molecular research and therapies. The impact of molecular research on the field of hematology is significant???molecular techniques are continuing to play a central role in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has increased our comprehension of the causes of hematological diseases and led to the development of new drug therapies and recombinant proteins. Now in its fourth edition, Molecular Hematology has been thoroughly revised and updated to reflect current advances in molecular research. Chapters introduce and summarize specific disorders, such as hemophilia, anemia, and multiple myeloma, and illustrate the impact of molecular research on their diagnoses and treatments. Contributions written by respected clinicians and researchers offer accessible coverage of topics including lymphoma genetics, molecular coagulation and thrombophilia, platelet disorders, pharmacogenomics, and many others. Demonstrates the clinical relevance of molecular biology in hematology Provides overviews of recent advances in cancer cell biology, with an emphasis on leukemia and lymphoma Offers new and updated chapters written by an international team of expertsPresents new full-color charts, graphs, and illustrations Includes access to a Wiley Companion Digital Edition providing search across the book, downloadable illustrations and notation tools Molecular Hematology is an essential volume for both trainee and practicing hematologists and oncologists, molecular biologists, and research scientists working in the field of hematology.