In this issue of Gastroenterology Clinics, guest editor Dr. R. Balfour Sartor brings his considerable expertise to the topic of The Microbiome. Research on the gut microbiome has revealed significant implications for gastrointestinal diseases, with clinical trials resulting in potential treatments for the management of GI diseases and their associated risk factors. Further, understanding the gut microbiome’s role in gastrointestinal health opens avenues for targeted interventions and personalized approaches to disease management. This issue presents the latest research, treatments, and clinical approaches in this key area of gastroenterology. Contains 13 relevant, practice-oriented topics, including the role of intestinal microbiome in potentiating inflammation and predicting outcomes in alcoholic hepatitis; intestinal microbial modulation of therapeutic efficacy and complications of cancer immunotherapy; beyond fecal microbial transplant: next generation approaches to manipulating dysbiotic microbiota to treat IBD; dysbiotic microbiota in necrotizing enterocolitis; microbial approaches to treat and prevent hepatic encephalopathy; and more Provides in-depth clinical reviews on the microbiome, offering actionable insights for clinical practice Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews