Section 1: Closing Research Gaps.- Driver-Based Chronic Disease: A Novel Paradigm for Lifestyle Medicine Targeting.- Adiposity-Based Chronic Disease.- Dysglycemia Based Chronic Disease.- Hypertension-Based Chronic Disease.- The Novel Lipid-Based Chronic Disease Model in Lifestyle Medicine – Impact on Prevention of Atherosclerotic Cardiovascular Disease.- Cardiometabolic-Based Chronic Disease.- Malnutrition-Based Chronic Disease: A New Framework for Preventive Care.- Dietary Patterns for Cardiometabolic Risk Reduction: Moving from Evidence to Implementation.- Lifestyle Medicine Research and Implementation in Chronic Kidney Disease.- Effects of Lifestyle Interventions on Metabolic Dysfunction-Associated Steatotic Liver Disease.- Chronic Pulmonary Disease and Lifestyle Medicine.- Exercise and Diet in People with Inflammatory Arthritis and Osteoarthritis.- Lifestyle Medicine Approaches to Bone Health – State of the Field and Future Directions.- Comprehensive Cancer Care and Lifestyle Medicine.- Lifestyle Psychiatry.- The Exposome and Lifestyle Medicine: Research Gaps.- The Role of Artificial Intelligence in Advancing Lifestyle Medicine Research.- Section 2: Closing Knowledge Gaps.- Teaching Preventive Care Modalities.- Models for Lifestyle Medicine Education.- Online Lifestyle Medicine Curriculum – Development and Implementation.- Toward a Culture of Nutrition Training Programs for Physicians - Challenges and Rewards.- Accreditation Programs in Lifestyle Medicine – New Survey Data and A Proposed European Model.- Emergence of a New Medical Subspecialty: The Case of Obesity Medicine .- Section 3: Closing Practice Gaps.- Lifestyle Medicine and Inflammatory Bowel Disease.- Cognitive Aging and Neurodegenerative Disorders.- Healthy Eating for Diabetes .- Substance Abuse Prevention and Treatment – A Specialization in Lifestyle Medicine Centers.- Addressing Enviromental Risks for Chronic Diseases in a Lifestyle Medicine Practice.- Routine Change in Obesity and Type 2 Diabetes.- Pharmacotherapy De-Escalation as a Critical Component of Lifestyle Medicine.- Digital Health Technology and Advanced Analytics in Lifestyle Medicine.- Digital Twin Technology for Management of Chronic Metabolic Disease.- Home-Based Cardiac Rehabilitation.- Transculturalization and Globalization of Lifestyle Medicine.- Impact of Social Determinants of Health on Lifestyle Medicine Implementation.- The Lifestyle Medicine Center.- The Lifestyle Medicine Eco-System: Deriving an Infrastructure to Defragment Healthcare.

This book represents the third in a series of Springer textbooks on Lifestyle Medicine by Dr. Mechanick and Dr. Kushner. The first book focused on theory and practice concepts. The second book focused on implementation with a specific tactic of building a lifestyle medicine center. This third book focuses on scientific evidence to close research gaps, knowledge gaps, and practice gaps. The general intent is to imbue the field of lifestyle medicine with scientific evidence. The other intent is to continue advancing a culture of preventive care for chronic disease using lifestyle medicine, but again through a tactic of emphasizing science, evidence, and critical thinking.

Lifestyle Medicine: Closing Research, Practice, and Knowledge Gaps is organized into three sections. In the first section, driver-based chronic disease models and other elements that pertain to lifestyle medicine are explored in terms of current levels of scientific substantiation. In the second section, educational modalities are presented that can improve awareness of scientific and experiential knowledge by healthcare professionals. Topics include innovative teaching models, web-based activities, training and accreditation programs, and certification exams. In the third section, a variety of clinical scenarios are presented to highlight practice gaps – implementation issues where there is inadequate clinical action despite an awareness of the pertinent knowledge. The topics span critical domains that must be addressed so that lifestyle medicine can lead to favorable outcomes in people and populations at risk. These domains include: alcohol and substance abuse, colitis, brain health, environmental risk, pharmacotherapy de-escalation, routine change, socioeconomics, transculturalization, advanced analytics, home cardiac rehabilitation, digital twin technology, and a highly referenced discussion of the lifestyle medicine ecosystem and infrastructure. Care is taken to provide not only theoretical foundations but also case studies, where appropriate, to emphasize critical aspects.

In conclusion, this third book on Lifestyle Medicine will complement the previous two Springer books and define a compendium of resources necessary for anyone interested in this field.