There has been a rapid evolution in the field of inhalation drug therapy, including new drugs, increased regulation and quality control, and strong pressure from generics. Inhalation Drug Therapy brings together the most current inhalation drug research, as well as practical developments and processes, into one essential guide.

List of contributors xi Series foreword xiii Preface xv 1 Inhalation drug delivery 1Daniela Traini 2 Inhalation and nasal products 15 Daniela Traini and Paul M. Young 3 Formulation of inhalation medicines 31 Daniela Traini and Paul M. Young 4 Novel particle production technologies for inhalation products 47 Hak-Kim Chan and Philip Chi Lip Kwok 5 Methods for understanding, controlling, predicting, and improving drug product performance 63 David A. V. Morton 6 Aerodynamic assessment for inhalation products: fundamentals and current pharmacopoeial methods 91 Francesca Buttini, Gaia Colombo, Philip Chi Lip Kwok and Wong Tin Wui 7 Proteins, peptides, and controlled-release formulations for inhalation 121 Philip Chi Lip Kwok, Rania Osama Salama and Hak-Kim Chan 8 Pharmaceutical development studies for inhalation products 145 Gaia Colombo, Chiara Parlati and Paola Russo 9 Quality of inhalation products: specifications 169 Paolo Colombo, Francesca Buttini and Wong Tin Wui Index.

The lung offers a unique and challenging route for drug administration for the treatment of local respiratory and systemic diseases. Advances in drug product formulation and inhalation device design are creating new opportunities for inhaled drug delivery as an alternative to oral and parenteral routes. However, the process of delivering drugs to the lung is complex and related to factors associated with the inhaled products and the patient. This book aims to provide a comprehensive and up to date understanding of the processes and mechanisms involved in inhalation drug delivery, with a strong focus on inhalation products, specific equipment and laboratory techniques. Students studying Pharmacy, Pharmaceutical Science and technology, Medicine or in general Life Science and Technology, at both undergraduate levels, will find this a concise resource, bringing new perspectives from a variety of research field balanced with industrial aspects.