Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV).

Heat Shock Proteins and Neurodegenerative Diseases.- Chaperones and Polyglutamine Expansion Disorders.- Heat Shock Proteins, Unfolded Protein Response Chaperones and Alzheimer’s Disease.- Cellular and Molecular Mechanisms Underlying Parkinson’s Disease: The Role of Molecular Chaperones.- Heat Shock Proteins as Therapeutic Targets in Amyotrophic Lateral Sclerosis.- The Role of Chaperones and Co-Chaperones in Retinal Degenerative Diseases.- Neuroprotective Features Of Hsp90 Inhibitors Exhibiting Anti-Inflammatory Actions: Implications For Multiple Sclerosis.- Role of HspB1 and HspB8 in Hereditary Peripheral Neuropathies: Beyond the Chaperone Function.- Heat Shock Proteins and Neuroprotection.- Heat Shock Proteins Hsp70 and Hsp27 and Neural Cellular Protection.- Molecular Chaperones and Protection in Animal and Cellular Models of Ischemic Stroke.- Strategies for Conferring Neuroprotection and Countering the High Threshold for Induction of the Stress Response in Motor Neurons.- Use of Viral Gene Delivery Systems to Investigate the Neuroprotective Roles of Hsp70 and Hsp40 Proteins.- Heat Shock Proteins at the Synapse: Implications for Functional Protection of the Nervous System.- Extracellular Heat Shock Proteins and The Nervous System.- Release of Heat Shock Proteins and their Effects When in the Extracellular Space in the Nervous System.- Silencing of Metastasis-associated Gene 1 (Mta1) Stimulates Hsp70 Cellular Release and Neurite extension in Neuroblastoma Cells.- Extracellular Chaperones and Amyloids.- Aging, Control Of Life Span and Expression Of Heat Shock Proteins.- Neural Expression Of Small Heat Shock Proteins Influences Longevity And Resistance To Oxidative Stress.- Mechanistic Links Between Aging and Aggregation-Mediated Proteotoxicity: Role of HSF-1 andDAF-16.- Protein Quality Control and Heat Shock Gene Expression in the Nervous System.- Serum Hsp70 Level as a Biomarker of Exceptional Longevity.- Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection.

Written by leaders in the field of neurodegenerative diseases and neuroprotection Provides up-to-date reviews on the most recent concepts of the role of heat shock proteins in repair and protective mechanisms in the brain Contains chapters with in-depth reviews on i) heat shock proteins and neurodegenerative diseases, ii) heat shock proteins and neuroprotection, iii) extracellular heat shock proteins and the nervous system and iv) aging, control of life span and expression of heat shock proteins

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