As part of the American Medical Association (AMA)’s Accelerating Change in Medical Education Consortium’s work, Health Systems Science (HSS) is establishing itself as the third major branch of a balanced medical education, alongside basic and clinical sciences. Health Systems Science Review is a first-of-its-kind review book designed to prepare future physicians and other health care professionals to function effectively within health systems by better understanding how health care is delivered, how health care professionals work together to deliver that care, and how the health system can improve patient care and health care delivery. This study tool provides case-based questions followed by discussions of answers and suggested readings—making it a valuable review resource for medical students and instructors, as well as medical residents; nursing, allied health, and public health students; and hospital administrators.