Harnessing Endogenous Mechanisms for Targeted Drug Delivery explores the cutting-edge advancements in the world of targeted drug delivery leveraging human biological mechanisms. This essential guide addresses the urgent need to enhance the efficiency of drug delivery and foster safe and effective therapies, particularly for biological agents like proteins, peptides, and nucleic acid molecules. The book offers a comprehensive exploration of tissue- and cell-specific delivery methods, emphasizing endogenous or biological techniques that can be utilized to improve drug delivery. It identifies the challenges associated with delivering complex molecules and accessing hard-to-reach sites, and provides practical solutions through endogenous strategies. Topics such as exploiting disease-specific stimuli to enhance delivery efficiency, the role of plasma proteins in drug delivery, and the utilization of extracellular vesicles to boost delivery efficiency are presented. Harnessing Endogenous Mechanisms for Targeted Drug Delivery emphasizes the clinical and commercial translation of these techniques, making this book an ideal resource for researchers, clinicians, and anyone interested in the future of drug delivery.
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Section 1: Drug Delivery Challenges and Opportunities 1. Contemporary Drug Delivery Challenges 2. Delivery Barriers 3. Strategies for Targeted Drug Delivery Section 2: Endogenous Strategies 4. Stimuli-Responsive Delivery 5. Glyco-Targeting using Lectins 6. Delivery using Plasma Proteins or Endogenous Peptides 7. Utilizing Virus Engineering in Drug Delivery 8. Living or artificial Cells as Trojan Horse-Cloaking Particles 9. Augmenting Cellular Cargo Capacity 10. Cell- and Bacterial-Derived Extracellular Vesicles-Based Targeted Delivery 11. Nucleic acid based delivery systems Section 3: Clinical Translation 13. Challenges Associated with Endogenous Targeting – Preclinical to clinical, scalability, toxicity 14. Current Clinical Trials 15. Clinical and Commercial Translational Challenges
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A complete guide to leverage biological mechanisms to overcome barriers and deliver therapeutic molecules across tissues and organ systems
Provides comprehensive insights into endogenous strategies for targeted drug delivery Highlights innovative techniques like using cells as Trojan Horse-Cloaking Particles Explores the clinical and commercial translation of these strategies Offers practical solutions to contemporary challenges in the area Emphasizes the role of disease-specific stimuli and plasma proteins in drug delivery
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Produktdetaljer

ISBN
9780443274299
Publisert
2025-12-01
Utgiver
Elsevier Science Publishing Co Inc; Academic Press Inc
Vekt
450 gr
Høyde
235 mm
Bredde
191 mm
Aldersnivå
P, 06
Språk
Product language
Engelsk
Format
Product format
Kombinasjonsprodukt
Antall sider
550

Om bidragsyterne

Dr. D’Souza is a Research Fellow at Massachusetts Eye and Ear Infirmary, Harvard Medical School, and is a Visiting Scholar at the Northeastern University, Department of Pharmaceutical Sciences, in Boston, MA. She earned her PhD (Tech.) in Pharmaceutics from the Department of Pharmaceutical Sciences and Technology at the Institute of Chemical Technology, Mumbai (ICT, formerly UDCT). Following her postdoctoral at IIT-Bombay, she served as a Research Formulation Scientist at Piramal Enterprises Limited, Mumbai. In this role, she contributed to projects achieving successful Abbreviated New Drug Application (ANDA) approvals by the US FDA. Dr. D’Souza’s research interests primarily revolve around colloidal drug delivery systems, viz., polymeric and solid lipid nanoparticles for enhanced bioavailability, controlled delivery and targeting. Additionally, she also explores nucleic acid delivery platforms for addressing CNS-related neurodegenerative disorders. She has published research papers and reviews in peer-reviewed journals, authored numerous book chapters, and co-edited a Springer-published book titled “Targeted Intracellular Drug Delivery by Receptor-Mediated Endocytosis”. Dr. Lara Milane is Assistant Teaching Professor in Biotechnology at the Bouvé College of Health Sciences at Northeastern University. She is interested in Mitochondrial Medicine. She is working on developing nanomedicines for a range of diseases (cancer, neurodegenerative disease, aging) that manipulate mitochondria for therapeutic outcomes. Dr. Milane was trained as a National Cancer Institute/ National Science Foundation Nanomedicine Fellow at Northeastern University, Boston, MA. Dr. Milane is an intuitive cancer biologist with research interests in developing translational nanomedicines that exploit the hallmarks of cancer. Mansoor M. Amiji is the Distinguished Professor and Chairman of the Department of Pharmaceutical Sciences at the Bouvé College of Health Sciences at Northeastern University. Dr. Amiji has edited a number of books and is a frequently published author. His research focuses on the synthesis of novel polymeric materials for medical and pharmaceutical applications, drug delivery systems and nanomedical technologies, and his contributions in research advising, grant reviews for various organizations and editorial work for journals are invaluable.