Preface vii About the companion website ix 1 An introduction to haematopoiesis 1 2 The blood count in health and disease 15 3 Anaemia: general principles 23 4 Haemolytic anaemias 39 5 Disorders of globin synthesis 55 6 An introduction to haematological malignancies 71 7 Cellular and molecular investigations in haematology 79 8 Neoplastic disorders of myeloid cells 91 9 Neoplastic disorders of lymphoid cells 105 10 Plasma cell myeloma and other paraproteinaemias 121 11 Aplastic anaemia and pure red cell aplasia 131 12 Stem cell transplantation and cellular therapy 137 13 Haemostasis and bleeding disorders 147 14 Thrombosis and anticoagulant therapy 163 15 Blood groups and blood transfusion 173 Index 187

HAEMATOLOGY Lecture Notes 11th Edition The Lecture Notes series provide concise, yet thorough, introductions to core areas of the undergraduate curriculum, covering both the basic science and the clinical approaches that all medical students and junior doctors need to know. For more information on all titles in the Lecture Notes series, please visit: www.wiley.com/en-gb/Lecture+Notes-c-2593 Lecture Notes: Haematology provides the basic subject knowledge required for understanding the pathogenesis and management of haematological disorders. This succinct, fully illustrated guide integrates all essential physiological, pathological, and clinical aspects of haematology in one easy-to-use volume. Now in its eleventh edition, Lecture Notes: Haematology includes new material on molecular and cellular diagnostics, new self-assessment questions in every chapter, and expanded coverage of haemostasis, anticoagulation, stem cell transplantation, and innovative cellular therapies for haematological malignancies. Featuring an updated companion website with over 150 multiple-choice questions across a series of evolving clinical cases, Lecture Notes: Haematology, 11th Edition is a must-have resource for medical students and junior doctors looking to increase their expertise in this important medical specialty. Haematology Lecture Notes, Eleventh Edition is a must-have guide for medical students and junior doctors in Haematology placements and preparing for clinical examinations. For more information on the complete range of Wiley medical student and junior doctor publishing, please visit: www.wiley.com To receive automatic updates on Wiley books and journals, join our email list. Sign up today at www.wiley.com/email This new edition is also available as an e-book. For more details, please see http://www.wiley.com/buy/9781119841227 All content reviewed by students for students Wiley Medical Education books are designed exactly for their intended audience. All of our books are developed in collaboration with students. This means that our books are always published with you, the student, in mind. If you would like to be one of our student reviewers, go to www.reviewmedicalbooks.com to find out more.