Pain management is a critical element of patient care, particularly in chronic disease. This genuinely evidence-based text for optimum pain relief in chronic illness provides the information on which to build more coherent and standardized strategies for pain relief.

List of contributors, v Preface, ix List of abbreviations, xi Part 1 Understanding evidence and pain, 1 1 Why evidence matters, 3 Andrew Moore and Sheena Derry 2 Clinical trial design for chronic pain treatments, 14 Alec B. O’Connor and Robert H. Dworkin 3 Introduction to evaluation of evidence, 31 Eija Kalso 4 Neurobiology of pain, 42 Victoria Harvey and Anthony Dickenson 5 Intractable pain and the perception of time: every patient is an anecdote, 52 David B. Morris 6 Psychology of chronic pain and evidence-based psychological interventions, 59 Christopher Eccleston Part 2 Clinical pain syndromes: the evidence, 69 7 Chronic low back pain, 71 Maurits van Tulder and Bart Koes 8 Chronic neck pain and whiplash, 83 Allan Binder 22 Headache, 279 Peer Tfelt-Hansen 23 Chest pain syndromes, 292 Austin Leach and Michael Chester Part 3 Cancer pain, 309 24 Oncologic therapy in cancer pain, 311 Rita Janes and Tiina Saarto 25 Cancer pain: analgesics and co-analgesics, 327 Rae Frances Bell 26 Psychologic interventions for cancer pain, 337 Francis J. Keefe, Tamara J. Somers and Amy Abernethy 27 Transcutaneous electrical nerve stimulation and acupuncture, 348 Mark I. Johnson Part 4 Treatment modalities: the evidence, 367 28 Interventional therapies, 369 Anthony Dragovich and Steven P. Cohen 29 Spinal cord stimulation for refractory angina, 400 Mats Börjesson, Clas Mannheimer, Paulin Andréll and Bengt Linderoth 30 Rehabilitative treatment for chronic pain, 407 James P. Robinson, Raphael Leo, Joseph Wallach, Ellen McGough and Michael Schatman 31 Drug treatment of chronic pain, 424 Henry McQuay 32 Complementary therapies for pain relief, 434 Edzard Ernst Index, 439

Section 1. 1 Why evidence matters. 2 Clinical trial designs for evaluating pharmacologic treatments for chronic pain. 3 Introduction to evaluation of evidence. 4 Neurobiology of pain. 5 Pain and suffering in context. 6 Psychology of pain. Section 2. 7 Low back pain (Pain related to lumbar spondylosis, Post-surgical back pain, Lumbar radiculopathy). 8 Neck pain (cervical spondylosis, Cervical radiculopathy, Whiplash). 9 Pain associated with Osteoarthritis. 10 Pain associated with Rheumatoid arthritis. 11 Fibromyalgia and Myofascial Pain. 12 Facial pain. 13 Chronic pelvic and perineal pain in women. 14 Perineal pain in males. 15 Pain from abdominal viscera. 16 Post-surgical pain syndromes. 17 Painful diabetic neuropathy. Post Herpetic Neuralgia. 18 Phantom limb pain. 19 CRPS - Complex regional pain syndrome. 20 Central pain syndromes. 21 Headache. 22 Chest pain syndromes. 23 Cancer Pain:. Oncological therapy in cancer pain. Analgesics and adjuvants in cancer pain management. Psychological Interventions for Cancer Pain. TENS and acupuncture for cancer pain. Section 3. 24 Interventional therapies. 25 Physical and behavioral interventions. 26 Pharmacological therapies. 27 Complementary therapies