This book describes control of ventilation during sleep in both health and disease states. The topics are presented in a fashion that can be easily comprehended with many figures to illustrate complex concepts.

Foreword. Preface. About the Editors. List of Contributors. ANATOMY, DEVELOPMENT, AGING, AND MECHANISMS OF CONTROL OF VENTILATION. Anatomy of the Respiratory Neural Network. Chemoreception: Pathways, Plasticity, and Pathophysiology. Developmental Changes in the Respiratory System of the Neonate-Child. Control of Breathing in Older Adults. Breathing Control in Exercise. Control of the Upper Airway during Sleep. PATHOPHYSIOLOGY OF SLEEP-DISORDERED BREATHING. Pathophysiology of Sleep-Disordered Breathing in Children and Neonates. Pathogenesis of Sleep-Disordered Breathing in Adults: Overview. Risk and Causality by Genetics, Gender, and Age. The Influence of Cerebral Blood Flow and Cerebrovascular Responsiveness on Ventilatory Control. Central Apnea: Propensity and Plasticity. SLEEP-DISORDERED BREATHING IN DIFFERENT CONDITIONS AND DISEASE STATES. Sleep-Disordered Breathing due to Heart Failure. Breathing at Altitude. Sleep-Disordered Breathing Associated with Chronic Lung Diseases. Obesity Hypoventilation Syndrome. PATHOPHYSIOLOGY-DIRECTED THERAPIES FOR SLEEP-DISORDERED BREATHING. Effect of Positive Airway Pressure on Ventilatory Control and Sleep-Disordered Breathing. Mild Intermittent Hypoxia and Supplemental Oxygen: Potential Therapeutic Interventions to Treat Breathing Instability. Pharmacological Management of Sleep-Disordered Breathing. Neural Mechanisms Regulating Opioid-Induced Respiratory Depression and Therapeutic Strategies to Alleviate the Respiratory Side-Effects of Opioid Drugs. Pharmacologic Intervention Studies to Mitigate Breathing Instability – Animal Studies. Index.